P142 Cytomegalovirus seropositivity is associated with an increased frequency of highly differentiated T effector memory cells re-expressing CD45RA (Temra) and persistent disease refractory to anti-TNF therapy in rheumatoid arthritis
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DOI: 10.1093/rheumatology/kead104.183
Abstract: The role of highly differentiated T effector memory re-expressing CD45RA (Temra) in rheumatoid arthritis (RA) is unclear, including whether they can be used as a marker of persistent disease activity. Our aim was to investigate… read more here.
Keywords: anti tnf; temra; persistent disease; frequency ... See more keywords
Epigenetic quantification of immunosenescent CD8+ TEMRA cells in human blood
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DOI: 10.1111/acel.13607
Abstract: Age‐related changes in human T‐cell populations are important contributors to immunosenescence. In particular, terminally differentiated CD8+ effector memory CD45RA+ TEMRA cells and their subsets have characteristics of cellular senescence, accumulate in older individuals, and are… read more here.
Keywords: temra cells; cell; epigenetic quantification; temra ... See more keywords
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
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DOI: 10.1136/jitc-2021-002709
Abstract: Background CD8+ tumor-infiltrating lymphocytes (TILs) comprise phenotypically and functionally heterogeneous subpopulations. Of these, effector memory CD45RA re-expressing CD8+ T cells (Temra) have been discovered and characterized as the most terminally differentiated subset. However, their exact… read more here.
Keywords: cd8; tumor antigens; immunogenicity tumor; cd8 tils ... See more keywords
Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8+ T Cells in Human Donors Allows the Detection of a TEMRA Subpopulation
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DOI: 10.3389/fimmu.2019.03110
Abstract: Pre-existing immunity to AAV capsid may compromise the safety and efficiency of rAAV-mediated gene transfer in patients. Anti-capsid cytotoxic immune responses have proven to be a challenge to characterize because of the scarcity of circulating… read more here.
Keywords: specific cd8; cd8; cd8 cells; aav8 ... See more keywords