Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
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DOI: 10.1016/j.vascn.2020.106871
Abstract: INTRODUCTION The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative differentiates torsadogenic risk of 28 drugs affecting ventricular repolarization based on multiple in vitro human derived ionic currents. However, a standardized prospective assessment of the electrophysiologic… read more here.
Keywords: qtc prolongation; torsadogenic risk; model; ten cipa ... See more keywords