DNA methylcytosine dioxygenase ten-eleven translocation 2 enhances lipopolysaccharide-induced cytokine expression in human dental pulp cells by regulating MyD88 hydroxymethylation
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2826-x
Abstract: Dental pulp inflammation is a bacterially driven inflammation process characterized by the local accumulation of cytokines/chemokines that participate in destructive processes in the pulp. Multiple mechanisms are involved in dental pulp inflammation, including epigenetic events,… read more here.
Keywords: ten eleven; expression; dental pulp; eleven translocation ... See more keywords
Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.061
Abstract: SUMMARY 5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be… read more here.
Keywords: response; crs; ten eleven; stress ... See more keywords
Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43539
Abstract: Muscle cell differentiation is a complex process that is principally governed by related myogenic regulatory factors (MRFs). DNA methylation is considered to play an important role on the expression of MRF genes and on muscle… read more here.
Keywords: myoblast differentiation; ten eleven; expression; differentiation ... See more keywords
Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02161c
Abstract: DNA cytosine methylation (5-methylcytosine, 5mC) is the most important epigenetic mark in higher eukaryotes. 5mC in genomes is dynamically controlled by writers and erasers. DNA (cytosine-5)-methyltransferases (DNMTs) are responsible for the generation and maintenance of… read more here.
Keywords: mammalian genomes; dna; demethylation; ten eleven ... See more keywords
Understanding the role of ten-eleven translocation family proteins in kidney diseases.
Sign Up to like & getrecommendations! Published in 2024 at "Biochemical Society transactions"
DOI: 10.1042/bst20240291
Abstract: Epigenetic mechanisms play a critical role in the pathogenesis of human diseases including kidney disorders. As the erasers of DNA methylation, Ten-eleven translocation (TET) family proteins can oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC),… read more here.
Keywords: family; role; family proteins; kidney ... See more keywords
Loss of Ten-Eleven Translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab046
Abstract: The ten-eleven translocation (Tet) family of dioxygenases convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Previous studies have shown that 5hmC-mediated epigenetic modifications play essential roles in diverse biological processes and diseases. Here we show that Tet proteins… read more here.
Keywords: cardiac hypertrophy; ten eleven; hypertrophy; erk signaling ... See more keywords
Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab167
Abstract: Allergic rhinitis (AR) is an allergen specific IgE-mediated inflammatory disease. Both genetic and environmental factors could play a role in the pathophysiology of AR. 5-methylcytosine (5-mC) can be converted to 5-hydroxymethylcytosine (5hmC) by the Ten-Eleven… read more here.
Keywords: translocation modulates; tet2; ten eleven; eleven translocation ... See more keywords
Ten-Eleven Translocation Ablation Impairs Cardiac Differentiation of Mouse Embryonic Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab017
Abstract: Ten-eleven Translocation (TET) dioxygenases mediated DNA methylation oxidation plays an important role in regulating the embryonic stem cells (ESCs) differentiation. Herein, we utilized a CRISPR/Cas9 based genome editing method to generate single, double, and triple… read more here.
Keywords: ten eleven; cardiac differentiation; differentiation; eleven translocation ... See more keywords
Role of Ten eleven translocation‐2 (Tet2) in modulating neuronal morphology and cognition in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15234
Abstract: Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis of Alzheimer's disease (AD). However, to date, the role of Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown in… read more here.
Keywords: tet2; ten eleven; model; expression ... See more keywords
High Expression of Ten Eleven Translocation 1 Is Associated with Poor Prognosis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Mediators of Inflammation"
DOI: 10.1155/2023/2664370
Abstract: Background DNA methylation patterns have been found to be distinct between tumor and normal patients. However, the effect of DNA demethylation enzymes, ten eleven translocation (TET) proteins, has not been comprehensively characterized in liver cancer.… read more here.
Keywords: hepatocellular carcinoma; ten eleven; prognosis; expression ... See more keywords
Ten-eleven translocation methyl-cytosine dioxygenase 2 deficiency exacerbates renal ischemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00892-8
Abstract: Background Ten-eleven translocation (Tet) methyl-cytosine dioxygenases (including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in embryonic development and adult tissue homeostasis. The expression of Tet2 and Tet3 genes are relatively abundant in the… read more here.
Keywords: renal ischemia; ten eleven; eleven translocation; injury ... See more keywords