Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability
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DOI: 10.1126/scitranslmed.aam6474
Abstract: Tenapanor inhibits sodium/hydrogen exchanger isoform 3 to reduce intestinal phosphate absorption via reduction of passive paracellular phosphate flux. Phosphate in flux Kidney failure can decrease the excretion of phosphate, leading to elevated phosphate in the… read more here.
Keywords: hydrogen exchanger; sodium; sodium hydrogen; tenapanor ... See more keywords
The NHE3 Inhibitor Tenapanor Prevents Intestinal Obstructions in CFTR-Deleted Mice
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DOI: 10.3390/ijms23179993
Abstract: Mutations in the CFTR chloride channel result in intestinal obstructive episodes in cystic fibrosis (CF) patients and in CF animal models. In this study, we explored the possibility of reducing the frequency of obstructive episodes… read more here.
Keywords: cftr mice; tenapanor; nhe3 inhibitor; mice ... See more keywords