Tenascin‐C aggravates ventricular dilatation and angiotensin‐converting enzyme activity after myocardial infarction in mice
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12794
Abstract: Tenascin‐C (TN‐C) is suggested to be detrimental in cardiac remodelling after myocardial infarction (MI). The aim of this study is to reveal the effects of TN‐C on extracellular matrix organization and its haemodynamic influence in… read more here.
Keywords: tenascin; ventricular dilatation; myocardial infarction; tenascin aggravates ... See more keywords
Tenascin C is dysregulated in hypoplastic lungs of miR-200b−/− mice
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Surgery International"
DOI: 10.1007/s00383-022-05096-0
Abstract: We previously demonstrated that absence of miR-200b results in abnormal lung development in congenital diaphragmatic hernia due to imbalance between epithelial and mesenchymal cells. Tenascin C is a highly conserved extracellular matrix protein involved in… read more here.
Keywords: tenascin; lung; lungs mir; mir 200b ... See more keywords
Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.06.047
Abstract: Tenascin C (Tnc) is an extracellular matrix glycoprotein, expressed in the CNS during development, as well as in the setting of inflammation, fibrosis and cancer, which operates as an activator of Toll-like receptor 4 (TLR4).… read more here.
Keywords: tenascin; microglia; tenascin regulates; regulates multiple ... See more keywords
Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis.
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf408
Abstract: OBJECTIVES Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodeling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA pathogenesis is… read more here.
Keywords: macrophages fibroblasts; tenascin; csf; csf csf ... See more keywords
Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/2009724
Abstract: Background Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular… read more here.
Keywords: tnc alarin; alarin levels; type diabetes; diabetes mellitus ... See more keywords
Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C–Derived Peptide TNIIIA2
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1251
Abstract: Tenascin-C is a member of the matricellular protein family, and its expression level is correlated to poor prognosis in cancer, including glioblastoma, whereas its substantial role in tumor formation and malignant progression remains controversial. We… read more here.
Keywords: integrin; activation; glioblastoma; tniiia2 ... See more keywords
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0074
Abstract: Tenascin-C, an extracellular matrix protein, contributes to immune suppression in head and neck tumors. Tenascin-C orchestrates immune-suppressive niches by directing spatial distribution of Tregs and myeloid cells, leading to invasive disease. Inherent immune suppression represents… read more here.
Keywords: tenascin; immune suppressive; orchestrates immune; oral squamous ... See more keywords
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320694
Abstract: Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a critical driver of vascular inflammation and atherosclerosis, and TGF-β (transforming growth factor β) is a key mediator of EndMT. Both EndMT and atherosclerosis are promoted by… read more here.
Keywords: endmt; endmt atherosclerosis; flow; tgf ... See more keywords
Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-025-02780-y
Abstract: Diabetic cardiomyopathy (DCM) is a complex condition linked to diabetes, characterized by cardiac and vascular dysfunction, frequently concomitant with heart failure with preserved ejection fraction. The extracellular matrix glycoprotein Tenascin-C (TNC) has been found to… read more here.
Keywords: tenascin; heart; diabetic cardiomyopathy; dysfunction ... See more keywords
T/T homozygosity of the tenascin-C gene polymorphism rs2104772 negatively influences exercise-induced angiogenesis
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DOI: 10.1371/journal.pone.0174864
Abstract: Background Mechanical stress, including blood pressure related factors, up-regulate expression of the pro-angiogenic extracellular matrix protein tenascin-C in skeletal muscle. We hypothesized that increased capillarization of skeletal muscle with the repeated augmentation in perfusion during… read more here.
Keywords: tenascin; angiogenesis; muscle; training ... See more keywords
Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23919
Abstract: The clinical outcome of T-cell non-Hodgkin lymphoma (NHL) is poor and innovative treatments are needed. Tenascin-C is a large extracellular glycoprotein not expressed under physiological conditions, but overexpressed in cancer. Aim of the study was… read more here.
Keywords: tenascin; cell non; cell nhl; non hodgkin ... See more keywords