Jitterbug/Filamin and Myosin-II form a complex in tendon cells required to maintain epithelial shape and polarity during musculoskeletal system development
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.09.002
Abstract: During musculoskeletal system development, mechanical tension is generated between muscles and tendon-cells. This tension is required for muscle differentiation and is counterbalanced by tendon-cells avoiding tissue deformation. Both, Jbug/Filamin, an actin-meshwork organizing protein, and non-muscle… read more here.
Keywords: myosin; jbug filamin; tendon cells; filamin ... See more keywords
Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/2040622320956429
Abstract: Background: Increasing evidence indicates that secretion of high mobility group box 1 protein (HMGB-1) is functionally associated with tendinopathy development. However, the underlying effect and mechanism of extracellular HMGB-1 on tendon cells are unclear. Methods:… read more here.
Keywords: tendon tissues; inflammatory signaling; extracellular hmgb; tendon cells ... See more keywords
A2A adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields
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DOI: 10.1371/journal.pone.0239807
Abstract: Tendinopathy is a degenerative disease in which inflammatory mediators have been found to be sometimes present. The interaction between inflammation and matrix remodeling in human tendon cells (TCs) is supported by the secretion of cytokines… read more here.
Keywords: electromagnetic fields; response; tcs; tendon ... See more keywords
Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-Enthesis
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DOI: 10.7150/ijbs.79007
Abstract: Large joints are composed of two closely linked cartilages: articular cartilage (AC; rich in type II collagen, a well-studied tissue) and fibrocartilaginous enthesis (FE; rich in type I collagen, common disorder sites of enthesopathy and… read more here.
Keywords: tendon cells; fibrocartilage; scxlin; humeral bone ... See more keywords