A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405711
Abstract: Preserving the function of human tendon‐derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non‐genetic approach is introduced to control the differentiation of hTDCs using a newly… read more here.
Keywords: htdcs; derived cells; tendon derived; tendon ... See more keywords
POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?
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DOI: 10.1002/advs.202507951
Abstract: Tendinous heterotopic ossification can cause pain and restricted joint mobility in affected areas, and it is a common and severe complication following tendon injuries. This condition significantly reduces the postoperative quality of life of patients,… read more here.
Keywords: traumatic heterotopic; heterotopic; heterotopic ossification; tendon derived ... See more keywords
In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor.
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DOI: 10.1007/7651_2021_432
Abstract: Bioreactors can offer an advanced platform to provide conditions that mimic the native microenvironment, which can also provide stretching environment for mechanobiology research. Tendon-derived stem cells (TDSCs) are a type of mechanosensitive and multipotent cells,… read more here.
Keywords: stimulation; derived stem; mechanical stimulation; tendon derived ... See more keywords
Pioglitazone attenuates advanced glycation end products‐induced apoptosis and calcification by modulating autophagy in tendon‐derived stem cells
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DOI: 10.1111/jcmm.14901
Abstract: Diabetes mellitus (DM) is one of the prominent risk factors for pathological development and progression of tendinopathy. One feature of DM‐related changes in tendinopathy is accumulation of advanced glycation end products (AGEs) in affected tendons.… read more here.
Keywords: apoptosis; derived stem; end products; glycation end ... See more keywords
Zonal characterization and differential trilineage potentials of equine intrasynovial deep digital flexor tendon-derived cells
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DOI: 10.1186/s12917-021-02793-1
Abstract: Background Intrasynovial deep digital flexor tendon (DDFT) injuries occur frequently and are often implicated in cases of navicular disease with poor outcomes and reinjuries. Cell-based approaches to tendon healing are gaining traction in veterinary medicine… read more here.
Keywords: digital flexor; intrasynovial deep; tendon; tendon derived ... See more keywords
Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway
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DOI: 10.1186/s13018-024-04915-5
Abstract: Oncostatin M (OSM) is involved in the regulation of osteogenic differentiation and has a major role in the development of heterotopic ossification. The role of OSM in osteogenic differentiation of tendon-derived stem cells (TDSCs) and… read more here.
Keywords: differentiation; differentiation tendon; osm; signalling pathway ... See more keywords
Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products
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DOI: 10.1371/journal.pone.0271770
Abstract: Background Tendon pathologies affect a large portion of people with diabetes. This high rate of tendon pain, injury, and disease appears to manifest independent of well-controlled HbA1c and fasting blood glucose. Advanced glycation end products… read more here.
Keywords: tendon derived; advanced glycation; end products; derived fibroblasts ... See more keywords