The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14333
Abstract: The therapeutic potential of mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) for various diseases and tissue repair is attracting attention. Here, EVs from conditioned medium of human bone marrow MSCs at passage 5 (P5) and… read more here.
Keywords: tendon healing; achilles tendon; msc; msc evs ... See more keywords
Oriented Fibers Cooperate with DFO to Prevent Tendon Adhesions by Improving the Repair Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202300054
Abstract: To solve the problem of tendon adhesion after an operation, an anti‐adhesion membrane is designed, which can inhibit the exogenous healing of tendons and promote endogenous healing. Here, poly[3(S)‐methyl‐morpholine‐2,5‐dione‐co‐lactic acid] P(MMD‐co‐LA) containing alanine units is… read more here.
Keywords: tendon healing; adhesion; microenvironment; fibers cooperate ... See more keywords
Mesenchymal stem cells for tendon healing: what is on the horizon?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2209
Abstract: Tendon injuries are a noteworthy morbidity but at present there are few effective scientifically proven treatments. In recent decades, a number of new strategies including tissue engineering with mesenchymal stem cells (MSCs) have been proposed… read more here.
Keywords: stem cells; cells tendon; tendon healing; mesenchymal stem ... See more keywords
Long-term local PDGF delivery using porous microspheres modified with heparin for tendon healing of rotator cuff tendinitis in a rabbit model.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.017
Abstract: In this study, we prepared the platelet-derived growth factor-containing porous microspheres modified with heparin (PDGF/Hep-PMSs) and investigated their anti-inflammatory and tendon healing effects on rotator cuff (RC) tendinitis rabbit model. PDGF/Hep-PMSs suppressed the mRNA levels… read more here.
Keywords: pdgf hep; long term; tendon; tendon healing ... See more keywords
Arthroscopic rotator cuff repair: magnetic resonance arthrogram assessment of tendon healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of shoulder and elbow surgery"
DOI: 10.1016/j.jse.2019.02.024
Abstract: BACKGROUND Many poor outcomes after arthroscopic rotator cuff (RC) repair relate to failure of tendon healing. The purposes of this study were to provide a better understanding of the magnetic resonance arthrography (MRA) characteristics of… read more here.
Keywords: arthroscopic rotator; rotator cuff; magnetic resonance; tendon healing ... See more keywords
Efficacy of Biologics for Ligamentous and Tendon Healing
Sign Up to like & getrecommendations! Published in 2020 at "Operative Techniques in Sports Medicine"
DOI: 10.1016/j.otsm.2020.150755
Abstract: The use of “biologics” has become increasingly popular over the past several decades due to their potential to treat various pathologies by providing supraphysiological doses of anabolic growth factors. Within orthopaedic sports medicine, biologic treatments… read more here.
Keywords: medicine; ligamentous tendon; biologic; efficacy biologics ... See more keywords
Wnt3a-Modified Nanofiber Scaffolds Facilitate Tendon Healing by Driving Macrophage Polarization during Repair.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20386
Abstract: Inflammation is part of the natural healing response, but persistent inflammatory events tend to contribute to pathology changes of tendon or ligament. Phenotypic switching of macrophages within the inflammatory niche is crucial for tendon healing.… read more here.
Keywords: tendon healing; nanofiber scaffolds; modified nanofiber; polarization ... See more keywords
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-021-00810-0
Abstract: Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with… read more here.
Keywords: enhanced tendon; side; capacity; drug ... See more keywords
A fine balance in tendon healing
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0432-0
Abstract: Tendons have limited regenerative potential, and injuries often cause scarring. A study now identifies a tendon stem cell population that contributes to regeneration and a tendon fibro–adipogenic progenitor population involved in fibrosis. read more here.
Keywords: balance tendon; fine balance; biology; tendon healing ... See more keywords
Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-07124-4
Abstract: To better understand the molecular mechanisms of tendon healing, we investigated the Murphy Roth’s Large (MRL) mouse, which is considered a model of mammalian tissue regeneration. We show that compared to C57Bl/6J (C57) mice, injured… read more here.
Keywords: altered tgfb1; tendon healing; mouse; mice ... See more keywords
High-fat diet, adipokines and low-grade inflammation are associated with disrupted tendon healing: a systematic review of preclinical studies.
Sign Up to like & getrecommendations! Published in 2021 at "British medical bulletin"
DOI: 10.1093/bmb/ldab007
Abstract: BACKGROUND The aetiopathogenesis of tendinopathy is uncertain, but inflammation may play a role in the early phase of tendinopathy and in tendon healing response. We investigated the most up-to-date evidence about the association between obesity,… read more here.
Keywords: fat diet; quality; systematic review; inflammation ... See more keywords