The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14333
Abstract: The therapeutic potential of mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) for various diseases and tissue repair is attracting attention. Here, EVs from conditioned medium of human bone marrow MSCs at passage 5 (P5) and… read more here.
Keywords: tendon healing; achilles tendon; msc; msc evs ... See more keywords
Oriented Fibers Cooperate with DFO to Prevent Tendon Adhesions by Improving the Repair Microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202300054
Abstract: To solve the problem of tendon adhesion after an operation, an anti‐adhesion membrane is designed, which can inhibit the exogenous healing of tendons and promote endogenous healing. Here, poly[3(S)‐methyl‐morpholine‐2,5‐dione‐co‐lactic acid] P(MMD‐co‐LA) containing alanine units is… read more here.
Keywords: tendon healing; adhesion; microenvironment; fibers cooperate ... See more keywords
CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406611
Abstract: Tendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is an extracellular matrix… read more here.
Keywords: cthrc1; mapk signaling; tendon healing; signaling pathway ... See more keywords
Mesenchymal stem cells for tendon healing: what is on the horizon?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2209
Abstract: Tendon injuries are a noteworthy morbidity but at present there are few effective scientifically proven treatments. In recent decades, a number of new strategies including tissue engineering with mesenchymal stem cells (MSCs) have been proposed… read more here.
Keywords: stem cells; cells tendon; tendon healing; mesenchymal stem ... See more keywords
Long-term local PDGF delivery using porous microspheres modified with heparin for tendon healing of rotator cuff tendinitis in a rabbit model.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.017
Abstract: In this study, we prepared the platelet-derived growth factor-containing porous microspheres modified with heparin (PDGF/Hep-PMSs) and investigated their anti-inflammatory and tendon healing effects on rotator cuff (RC) tendinitis rabbit model. PDGF/Hep-PMSs suppressed the mRNA levels… read more here.
Keywords: pdgf hep; long term; tendon; tendon healing ... See more keywords
Arthroscopic rotator cuff repair: magnetic resonance arthrogram assessment of tendon healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of shoulder and elbow surgery"
DOI: 10.1016/j.jse.2019.02.024
Abstract: BACKGROUND Many poor outcomes after arthroscopic rotator cuff (RC) repair relate to failure of tendon healing. The purposes of this study were to provide a better understanding of the magnetic resonance arthrography (MRA) characteristics of… read more here.
Keywords: arthroscopic rotator; rotator cuff; magnetic resonance; tendon healing ... See more keywords
Efficacy of Biologics for Ligamentous and Tendon Healing
Sign Up to like & getrecommendations! Published in 2020 at "Operative Techniques in Sports Medicine"
DOI: 10.1016/j.otsm.2020.150755
Abstract: The use of “biologics” has become increasingly popular over the past several decades due to their potential to treat various pathologies by providing supraphysiological doses of anabolic growth factors. Within orthopaedic sports medicine, biologic treatments… read more here.
Keywords: medicine; ligamentous tendon; biologic; efficacy biologics ... See more keywords
Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Nano Letters"
DOI: 10.1021/acs.nanolett.4c01540
Abstract: Inspired by the imbalance between extrinsic and intrinsic tendon healing, this study fabricated a new biofilter scaffold with a hierarchical structure based on a melt electrowriting technique. The outer multilayered fibrous structure with connected porous… read more here.
Keywords: biofilter tube; tendon healing; biofilter; scarless tendon ... See more keywords
Wnt3a-Modified Nanofiber Scaffolds Facilitate Tendon Healing by Driving Macrophage Polarization during Repair.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c20386
Abstract: Inflammation is part of the natural healing response, but persistent inflammatory events tend to contribute to pathology changes of tendon or ligament. Phenotypic switching of macrophages within the inflammatory niche is crucial for tendon healing.… read more here.
Keywords: tendon healing; nanofiber scaffolds; modified nanofiber; polarization ... See more keywords
Nanopeptides-Loaded Electro-Assembled Oriented Collagen Matrix for the Synergistically Promotes Early Angiogenesis in Tendon Healing.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c09232
Abstract: Angiogenesis is a critical process in the early stages of tendon healing but is always limited by its avascular structure, thus impairing effective healing. Nanopeptides targeting endogenous vascular endothelial growth factor (VEGF) presented a promising… read more here.
Keywords: collagen; tendon healing; early angiogenesis; vegf ... See more keywords
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-021-00810-0
Abstract: Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with… read more here.
Keywords: enhanced tendon; side; capacity; drug ... See more keywords