Heparin functionalization increases retention of TGF-β2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.03.017
Abstract: The tendon/ligament-to-bone transition (enthesis) is a highly specialized interphase tissue with structural gradients of extracellular matrix composition, collagen molecule alignment and mineralization. These structural features are essential for enthesis function, but are often not regenerated… read more here.
Keywords: ligament bone; enthesis; tissue; bone ... See more keywords
Biomimetic strategies for tendon/ligament-to-bone interface regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.01.022
Abstract: Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure, composition, cell population and mechanics of the interface. With rapid advances in tissue engineering, a variety of strategies including advanced biomaterials, bioactive growth… read more here.
Keywords: ligament bone; strategies tendon; regeneration; tendon ligament ... See more keywords
Driving Hierarchical Collagen Fiber Formation for Functional Tendon, Ligament, and Meniscus Replacement.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120527
Abstract: Hierarchical collagen fibers are the primary source of strength in musculoskeletal tendons, ligaments, and menisci. It has remained a challenge to develop these large fibers in engineered replacements or in vivo after injury. The objective… read more here.
Keywords: collagen; fiber formation; fiber; tendon ligament ... See more keywords
Implantable medical devices for tendon and ligament repair: a review of patents and commercial products
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Medical Devices"
DOI: 10.1080/17434440.2022.2142557
Abstract: ABSTRACT Introduction Tendon and ligament injuries are a frequent and debilitating issue that affects many patients worldwide. The predominant solution is the suture thread, which is not without potential side effects and limitations. Implantable medical… read more here.
Keywords: medical devices; tendon ligament; implantable medical; commercial products ... See more keywords
EP-482 What is the evidence from in vivo studies that mesenchymal stem cell derived extracellular vesicles can facilitate tendon and ligament repair?
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Surgery"
DOI: 10.1093/bjs/znac245.113
Abstract: Tendon and ligament injury pose an increasingly large burden to society. With surgical repair and grafting susceptible to failure, tissue engineering provides novel avenues for treatment. This systematic review explores evidence whether mesenchymal stem cell-derived… read more here.
Keywords: vivo; stem cell; mesenchymal stem; evidence ... See more keywords
RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn2138
Abstract: Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, the mechanisms of ectopic ossification… read more here.
Keywords: rspo2; ligament; ossification; ectopic ossification ... See more keywords
Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12050663
Abstract: A significant proportion of patients requiring musculoskeletal management present with tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms that lead to such disabilities is increasing. However, the complexity underpinning these interactive… read more here.
Keywords: ligament genetics; review; tendon ligament; injury ... See more keywords
Practical Considerations for Translating Mesenchymal Stromal Cell-Derived Extracellular Vesicles from Bench to Bed
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081684
Abstract: Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown potential for the treatment of tendon and ligament injuries. This approach can eliminate the need to transplant live cells to the human body, thereby… read more here.
Keywords: cell; extracellular vesicles; mesenchymal stromal; ligament injuries ... See more keywords
Wetspun Polymeric Fibrous Systems as Potential Scaffolds for Tendon and Ligament Repair, Healing and Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112526
Abstract: Tendon and ligament traumatic injuries are among the most common diagnosed musculoskeletal problems. Such injuries limit joint mobility, reduce musculoskeletal performance, and most importantly, lower people’s comfort. Currently, there are various treatments that are used… read more here.
Keywords: regeneration; wetspun polymeric; polymeric fibrous; tendon ligament ... See more keywords