Articles with "tendon stem" as a keyword



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A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis

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Published in 2019 at "Nature cell biology"

DOI: 10.1038/s41556-019-0417-z

Abstract: Tendon injuries cause prolonged disability and never recover completely. Current mechanistic understanding of tendon regeneration is limited. Here, we use single-cell transcriptomics to identify a tubulin polymerization-promoting protein family member 3-expressing (Tppp3+) cell population as… read more here.

Keywords: cell; regeneration; tendon stem; tppp3 pdgfra ... See more keywords
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Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration.

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Published in 2022 at "Biomaterials science"

DOI: 10.1039/d1bm01287h

Abstract: Poor tendon repair remains a clinical problem due to the difficulties in replicating the complex multiscale hierarchical structure of native tendons. In this work, a bioinspired fibrous scaffold with bimodal micro-nanofibers and a teno-inductive aligned… read more here.

Keywords: bimodal micro; progenitor cells; stem progenitor; micro nanofibrous ... See more keywords
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Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo

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Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/3945195

Abstract: Tendon stem cells (TSCs) are often exposed to oxidative stress at tendon injury sites, which impairs their physiological effect as well as therapeutic application. Recently, extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells… read more here.

Keywords: tendon stem; bmsc evs; eug bmsc; stem ... See more keywords
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Electrospun aligned poly(ε-caprolactone) nanofiber yarns guiding 3D organization of tendon stem/progenitor cells in tenogenic differentiation and tendon repair

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Published in 2022 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2022.960694

Abstract: Hierarchical anisotropy structure directing 3D cellular orientation plays a crucial role in designing tendon tissue engineering scaffolds. Despite recent development of fabrication technologies for controlling cellular organization and design of scaffolds that mimic the anisotropic… read more here.

Keywords: structure; tendon tissue; tenogenic differentiation; stem progenitor ... See more keywords
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Hepatocyte Growth Factor-Induced Tendon Stem Cell Conditioned Medium Promotes Healing of Injured Achilles Tendon

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Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.654084

Abstract: Tendon repair is a medical challenge. Our present study investigated the effectiveness of acellular therapy consisting of conditioned medium (CM) of tendon stem cells (TSCs) induced with hepatocyte growth factor (HGF) in promoting the healing… read more here.

Keywords: conditioned medium; injured achilles; tendon stem; achilles tendon ... See more keywords