Off-Label Use of Tenecteplase for the Treatment of Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.4506
Abstract: Key Points Question How does the use of tenecteplase compare with the use of alteplase in the clinical outcomes of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis? Findings In this systematic review and… read more here.
Keywords: use tenecteplase; tenecteplase; acute ischemic; use ... See more keywords
Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.1449
Abstract: Importance Symptomatic intracranial hemorrhage (sICH) is a serious complication of stroke thrombolytic therapy. Many stroke centers have adopted 0.25-mg/kg tenecteplase instead of alteplase for stroke thrombolysis based on evidence from randomized comparisons to alteplase as… read more here.
Keywords: tenecteplase; acute ischemic; tenecteplase alteplase; stroke ... See more keywords
Intra-Arterial Tenecteplase After Successful Reperfusion in Large Vessel Occlusion Stroke
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2025.2036
Abstract: This phase 1 and 2 randomized clinical trial investigated both the safety threshold and efficacy of 3 different doses of tenecteplase when given by catheter to patients with large vessel occlusion stroke after successful endovascular… read more here.
Keywords: vessel occlusion; occlusion stroke; tenecteplase; large vessel ... See more keywords
Intravenous Thrombolysis with Tenecteplase for the Treatment of Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26445
Abstract: Intravenous thrombolysis (IVT) with tenecteplase has been associated with better clinical outcomes in acute ischemic stroke (AIS) patients with confirmed large vessel occlusions compared to IVT with alteplase. However, the utility of tenecteplase for the… read more here.
Keywords: tenecteplase; acute ischemic; intravenous thrombolysis; tenecteplase treatment ... See more keywords
Tenecteplase versus alteplase for management of acute ischemic stroke: a pairwise and network meta-analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1721-3
Abstract: Tenecteplase is a genetically mutated variant of alteplase with superior pharmacodynamic and pharmacokinetic properties. However, its efficacy and safety in acute ischemic strokes are limited. Hence, we conducted a study to evaluate the efficacy and… read more here.
Keywords: ischemic stroke; acute ischemic; alteplase; network meta ... See more keywords
Efficacy and Safety of Tenecteplase in the Treatment of Acute Branch Atheromatous Disease: A Retrospective Multicenter Case–Control Study
Sign Up to like & getrecommendations! Published in 2025 at "Neurology and Therapy"
DOI: 10.1007/s40120-025-00807-w
Abstract: Branch atheromatous disease (BAD) is a common subtype of acute ischemic stroke characterized by atherosclerosis. Patients with BAD are highly prone to early neurological deterioration. Intravenous thrombolysis can restore blood flow. We investigated the efficacy… read more here.
Keywords: branch atheromatous; treatment; tenecteplase; atheromatous disease ... See more keywords
A comparative study of structure, stability and function of sc-tenecteplase in the presence of stabilizing osmolytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.05.014
Abstract: The aim of the present study was to investigate the effect of three routine drug excipients, as osmolytes, in three different concentrations, on structure, thermal stability and the activity of single-chain (sc-) tenecteplase. To see… read more here.
Keywords: presence; study; structure stability; stability ... See more keywords
Facteurs prédictifs d’hémorragie intracérébrale après thrombolyse intraveineuse par Tenecteplase
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DOI: 10.1016/j.neurol.2020.01.221
Abstract: Introduction La Tenecteplase presente un profil d’efficacite et de securite egal voire superieur a l’Alteplase dans la thrombolyse intraveineuse (IV) malgre son faible recul. Objectifs Identifier les facteurs cliniques et paracliniques accessibles a la phase… read more here.
Keywords: par tenecteplase; thrombolyse; thrombolyse intraveineuse; hemorragique ... See more keywords
Comparison of the safety and efficacy of dual antiplatelet therapy versus tenecteplase in patients with minor nondisabling acute ischemic stroke
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DOI: 10.1038/s41598-025-85969-1
Abstract: To evaluate the safety and efficacy of dual antiplatelet therapy (DAPT) versus tenecteplase in minor non-disabling acute ischemic stroke. This retrospective observational study utilized data from our stroke database. All consecutive patients with minor non-disabling… read more here.
Keywords: acute ischemic; ischemic stroke; tenecteplase; dual antiplatelet ... See more keywords
Comparative efficacy and safety of tenecteplase and alteplase in acute ischemic stroke: A pairwise and network meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Neurological Sciences"
DOI: 10.1101/2022.10.06.22280794
Abstract: Abstract Background: Studies on tenecteplase have been yielding mixed results on several important variables at different doses, thus hampering objective guideline recommendations in acute ischemic stroke management. This meta-analysis stratifies doses in order to refine… read more here.
Keywords: meta analysis; meta; efficacy; tenecteplase ... See more keywords
Occlusion site and outcomes in intra-arterial tenecteplase after successful endovascular therapy: a secondary analysis of the ANGEL-TNK trial
Sign Up to like & getrecommendations! Published in 2025 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/jnis-2025-024129
Abstract: Background Endovascular thrombectomy achieves macroreperfusion in large vessel occlusion (LVO) stroke, but only one-quarter of patients had excellent functional outcome. Adjunct intra-arterial (IA) tenecteplase could further improve the treatment effect, yet its efficacy across internal… read more here.
Keywords: mca; analysis; occlusion site; tenecteplase ... See more keywords