Off-Label Use of Tenecteplase for the Treatment of Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.4506
Abstract: Key Points Question How does the use of tenecteplase compare with the use of alteplase in the clinical outcomes of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis? Findings In this systematic review and… read more here.
Keywords: use tenecteplase; tenecteplase; acute ischemic; use ... See more keywords
Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.1449
Abstract: Importance Symptomatic intracranial hemorrhage (sICH) is a serious complication of stroke thrombolytic therapy. Many stroke centers have adopted 0.25-mg/kg tenecteplase instead of alteplase for stroke thrombolysis based on evidence from randomized comparisons to alteplase as… read more here.
Keywords: tenecteplase; acute ischemic; tenecteplase alteplase; stroke ... See more keywords
Intravenous Thrombolysis with Tenecteplase for the Treatment of Acute Ischemic Stroke
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DOI: 10.1002/ana.26445
Abstract: Intravenous thrombolysis (IVT) with tenecteplase has been associated with better clinical outcomes in acute ischemic stroke (AIS) patients with confirmed large vessel occlusions compared to IVT with alteplase. However, the utility of tenecteplase for the… read more here.
Keywords: tenecteplase; acute ischemic; intravenous thrombolysis; tenecteplase treatment ... See more keywords
Tenecteplase versus alteplase for management of acute ischemic stroke: a pairwise and network meta-analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1721-3
Abstract: Tenecteplase is a genetically mutated variant of alteplase with superior pharmacodynamic and pharmacokinetic properties. However, its efficacy and safety in acute ischemic strokes are limited. Hence, we conducted a study to evaluate the efficacy and… read more here.
Keywords: ischemic stroke; acute ischemic; alteplase; network meta ... See more keywords
A comparative study of structure, stability and function of sc-tenecteplase in the presence of stabilizing osmolytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.05.014
Abstract: The aim of the present study was to investigate the effect of three routine drug excipients, as osmolytes, in three different concentrations, on structure, thermal stability and the activity of single-chain (sc-) tenecteplase. To see… read more here.
Keywords: presence; study; structure stability; stability ... See more keywords
Facteurs prédictifs d’hémorragie intracérébrale après thrombolyse intraveineuse par Tenecteplase
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DOI: 10.1016/j.neurol.2020.01.221
Abstract: Introduction La Tenecteplase presente un profil d’efficacite et de securite egal voire superieur a l’Alteplase dans la thrombolyse intraveineuse (IV) malgre son faible recul. Objectifs Identifier les facteurs cliniques et paracliniques accessibles a la phase… read more here.
Keywords: par tenecteplase; thrombolyse; thrombolyse intraveineuse; hemorragique ... See more keywords
Comparative efficacy and safety of tenecteplase and alteplase in acute ischemic stroke: A pairwise and network meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Neurological Sciences"
DOI: 10.1101/2022.10.06.22280794
Abstract: Abstract Background: Studies on tenecteplase have been yielding mixed results on several important variables at different doses, thus hampering objective guideline recommendations in acute ischemic stroke management. This meta-analysis stratifies doses in order to refine… read more here.
Keywords: meta analysis; meta; efficacy; tenecteplase ... See more keywords
Abstract 80: The Experimental Neuroprotective Drug Na1 Does Not Interfere With the Fibrinolytic Activities of Alteplase or Tenecteplase
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/str.50.suppl_1.80
Abstract: Introduction: Tissue plasminogen activator (Alteplase; tPA) is the most commonly used thrombolytic medication for treatment of acute ischemic stroke, and recent research suggests that Tenecteplase ... read more here.
Keywords: na1 interfere; tenecteplase; abstract experimental; neuroprotective drug ... See more keywords
Abstract P21: Tenecteplase: As First Choice “Give and Go” Stroke Thrombolysis Treatment
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DOI: 10.1161/str.52.suppl_1.p21
Abstract: Tenecteplase (TNK) is more fibrin specific and has longer activity duration than Alteplase (ALT). Compared to ALT, recent acute stroke treatment studies have found TNK at doses up to 0.4mg/kg to ha... read more here.
Keywords: first choice; treatment; p21 tenecteplase; tenecteplase first ... See more keywords
Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice
Sign Up to like & getrecommendations! Published in 2022 at "Stroke"
DOI: 10.1161/strokeaha.122.038950
Abstract: Background: A 10-hospital regional network transitioned to tenecteplase as the standard of care stroke thrombolytic in September 2019 because of potential workflow advantages and reported noninferior clinical outcomes relative to alteplase in meta-analyses of randomized… read more here.
Keywords: tenecteplase versus; routine clinical; tenecteplase; door ... See more keywords
Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Stroke"
DOI: 10.1161/strokeaha.122.041061
Abstract: Background: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence alteplase-associated reperfusion. In this study, we assessed the reperfusion efficacy of tenecteplase and alteplase in subgroups based on these characteristics in… read more here.
Keywords: alteplase; versus alteplase; reperfusion; tenecteplase ... See more keywords