The dipeptidyl peptidase‐4 (DPP‐4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice
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DOI: 10.1002/2211-5463.12498
Abstract: To clarify the effects of a dipeptidyl peptidase‐4 (DPP‐4) inhibitor on whole‐body energy metabolism, we treated mice fed a high‐fat diet (HFD) with teneligliptin, a clinically available DPP‐4 inhibitor. Teneligliptin significantly prevented HFD‐induced obesity and… read more here.
Keywords: inhibitor; teneligliptin; obesity; dpp ... See more keywords
Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103111
Abstract: Type 2 diabetes mellitus (T2DM) is a disorder distinguished by resisting insulin effects and/or its reduced secretion leading to high blood sugar levels. It is fast becoming epidemic worldwide and is a major cause of… read more here.
Keywords: hplc; teneligliptin; method; dapagliflozin empagliflozin ... See more keywords
Efficacy and safety of teneligliptin add-on to insulin monotherapy in Japanese patients with type 2 diabetes mellitus: a 16-week, randomized, double-blind, placebo-controlled trial with an open-label period
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DOI: 10.1080/14656566.2017.1359259
Abstract: ABSTRACT Objective: To assess the efficacy and safety of teneligliptin as add-on to insulin monotherapy in patients with type 2 diabetes mellitus (T2DM). Research design and methods: In a 16-week, double-blind period, 148 Japanese T2DM… read more here.
Keywords: label period; teneligliptin; period; open label ... See more keywords
SAT-173 Antiproliferative Effect of Teneligliptin on Atherosclerosis in Vascular Smooth Muscle Cell
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DOI: 10.1210/js.2019-sat-173
Abstract: Abstract Background and aims: In vivo and in vitro studies revealed that sitagliptin, linagliptin treatment suppressed proliferation of vascular smooth muscle cells (VSMCs). However, data are lacking regarding the effects of teneligliptin. Here, we demonstrate… read more here.
Keywords: vascular smooth; phospho; teneligliptin; smooth muscle ... See more keywords
Teneligliptin enhances the beneficial effects of GLP-1 in endothelial cells exposed to hyperglycemic conditions
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DOI: 10.18632/oncotarget.22849
Abstract: High-glucose-induced oxidative stress contributes to cardiovascular endothelial damage in diabetes. Glucagon-like peptide 1 (GLP-1) is beneficial to endothelial cells, but its effects are diminished when cells are continuously exposed to high glucose. Teneligliptin is a… read more here.
Keywords: teneligliptin; hyperglycemic conditions; beneficial effects; stress ... See more keywords
Efficacy and Safety of Teneligliptin in Indian Patients with Inadequately Controlled Type 2 Diabetes Mellitus: A Randomized, Double-blind Study
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DOI: 10.4103/ijem.ijem_97_16
Abstract: Aims: This study evaluated the efficacy and safety of teneligliptin in patients with inadequately controlled type 2 diabetes mellitus (T2DM). Settings and Design: This was a randomized, doubleblind, placebocontrolled, parallelgroup, multicenter, Phase III study. Subjects… read more here.
Keywords: difference; teneligliptin; group; efficacy ... See more keywords
Suppression of Abdominal Aortic Aneurysm Formation in Mice by Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor
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DOI: 10.5551/jat.42481
Abstract: Aim: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels through inhibition of incretin degradation, which stimulates insulin secretion. Recent studies reported that DPP-4 inhibitors suppressed atherogenesis in apolipoprotein E-knockout (ApoEKO) mice. In this study, we… read more here.
Keywords: teneligliptin; control; formation; mice ... See more keywords
Analytical method development and validation of teneligliptin by rp-uflc
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DOI: 10.5958/0974-360x.2020.00713.1
Abstract: To estimate Teneligliptin by Ultra-Fast Liquid Chromatographic (RP-UFLC), a fast, reliable, and cost-effective UFLC method was developed. The approximate flowing rate was 1.0 mL/minfor the Phenomenex Kinetex column C18 (250mmx 4.6mm. 5 Micron) with MeOH… read more here.
Keywords: analytical method; method development; development validation; teneligliptin ... See more keywords