Determination of enantiomeric impurity of tenofovir disoproxil fumarate on a cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase and the characterization of its related substances.
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DOI: 10.1002/jssc.202100011
Abstract: A simple and reliable HPLC method was developed to determine the enantiomeric impurity of tenofovir disoproxil fumarate, an orally bioavailable prodrug of tenofovir, commonly used for the treatment of human immunodeficiency virus and hepatitis B.… read more here.
Keywords: tenofovir disoproxil; enantiomeric impurity; disoproxil fumarate; tenofovir ... See more keywords
Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.05.030
Abstract: ABSTRACT HIV pre‐exposure prophylaxis (PrEP) strategies have the potential to prevent millions of incident HIV infections each year. However, the efficacy of PrEP strategies has been plagued by issues of non‐adherence, likely because of the… read more here.
Keywords: development rectal; tenofovir; enema; prodrug ... See more keywords
Tenofovir-induced Stevens-Johnson syndrome in a patient with acute hepatitis B: A rare case report.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Pharmacists Association : JAPhA"
DOI: 10.1016/j.japh.2020.06.029
Abstract: OBJECTIVE To report a rare case of a hepatitis B patient who developed the Stevens-Johnson syndrome (SJS) secondary to tenofovir use. CASE SUMMARY A 61-year-old woman presented with complaints of jaundice, difficulty in swallowing, and… read more here.
Keywords: rare case; tenofovir; johnson syndrome; case ... See more keywords
Development and validation of a liquid chromatography‐MS/MS method for simultaneous quantification of tenofovir and efavirenz in biological tissues and fluids
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.12.028
Abstract: &NA; Millions of people worldwide live with human immunodeficiency virus (HIV) infection thus justifying the continuous search for new prevention and treatment strategies, including topical microbicide products combining antiretroviral drugs (ARVs) such as tenofovir (TFV)… read more here.
Keywords: tissues fluids; tenofovir; method; tfv ... See more keywords
Validation and implementation of liquid chromatographic‐mass spectrometric (LC–MS) methods for the quantification of tenofovir prodrugs
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.02.011
Abstract: Background: The nucleotide reverse transcriptase inhibitor tenofovir (TFV) is widely administered in a disoproxil prodrug form (tenofovir disoproxil fumarate, TDF) for HIV management and prevention. Recently, novel prodrugs tenofovir alafenamide fumarate (TAF) and hexadecyloxypropyl tenofovir… read more here.
Keywords: tenofovir; taf tfv; mass; tfv ... See more keywords
An O-Benzyl Phosphonamidate Prodrug of Tenofovir for the Treatment of Hepatitis B Virus Infection.
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DOI: 10.1021/acs.jmedchem.2c00869
Abstract: A series of new O-(substituted benzyl) phosphoramidate prodrugs of tenofovir for the treatment of hepatitis B virus (HBV) infections have been designed and synthesized. An investigation of structure-activity relationships revealed that the compound bearing an… read more here.
Keywords: tenofovir; benzyl; hepatitis virus; treatment hepatitis ... See more keywords
Design and in vitro evaluation of tenofovir-loaded vaginal gels for the prevention of HIV infections
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2017.1329835
Abstract: Abstract Infection with the human immunodeficiency virus (HIV) is affecting women disproportionally with increasing incidence rates over the last decades. Tenofovir is one of the most commonly used antiretroviral agents, which belongs to the nucleoside/nucleotide… read more here.
Keywords: prevention hiv; tenofovir; design vitro; hiv ... See more keywords
Switching from a regimen containing abacavir/lamivudine or emtricitabine/tenofovir disoproxil fumarate to emtricitabine/tenofovir alafenamide fumarate does not affect central nervous system HIV-1 infection
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Diseases"
DOI: 10.1080/23744235.2019.1670352
Abstract: Abstract Background: Despite suppressive antiretroviral therapy (ART), many HIV-infected individuals have low-level persistent immune activation in the central nervous system (CNS). There have been concerns regarding the CNS efficacy of tenofovir alafenamide fumarate (TAF) because… read more here.
Keywords: tenofovir; nervous system; central nervous; emtricitabine tenofovir ... See more keywords
Short Communication: Bioequivalence of Tenofovir and Emtricitabine After Coencapsulation with the Proteus Ingestible Sensor.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2018.0081
Abstract: Adherence to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC, Truvada®) is the primary determinant of HIV pre-exposure prophylaxis (PrEP) efficacy. Despite its importance, limitations exist in current methods of adherence quantification, restricting their implementation in the clinic. Proteus… read more here.
Keywords: bioequivalence; tenofovir; ingestible sensor; proteus ... See more keywords
Week 48 Resistance Analyses of the Once-Daily, Single-Tablet Regimen Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Adults Living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials
Sign Up to like & getrecommendations! Published in 2019 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2019.0111
Abstract: Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for… read more here.
Keywords: emtricitabine tenofovir; resistance; tenofovir; week ... See more keywords
1041. Tenofovir alafenamide associated weight change in persons living with HIV
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DOI: 10.1093/ofid/ofaa439.1227
Abstract: Persons living with human immunodeficiency virus (PLWH) have a higher incidence of developing obesity, diabetes, and cardiovascular disease. TAF, a newer formulation of tenofovir, has favorable effects on renal function and bone mineral density compared… read more here.
Keywords: tenofovir; change; persons living; taf ... See more keywords