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   Articles with "tenofovir alafenamide" as a keyword



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Pharmacokinetics of Tenofovir Alafenamide, Tenofovir, and Emtricitabine Following Administration of Coformulated Emtricitabine/Tenofovir Alafenamide in Healthy Japanese Subjects

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recommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.623

Abstract: A fixed‐dose combination of tenofovir alafenamide (TAF) and emtricitabine (FTC) is available in 2 tablet strengths in Japan (FTC/TAF 200/10 mg and FTC/TAF 200/25 mg). These are used once daily in combination with other antiretroviral… read more here.

Keywords: ftc taf; treatment; tenofovir alafenamide; taf 200 ... See more keywords
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Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV: a systematic review

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recommendations! Published in 2023 at "Journal of the International AIDS Society"

DOI: 10.1002/jia2.26037

Abstract: Tenofovir alafenamide (TAF) is approved for paediatric use in fixed‐dose combination tablets, but efficacy and safety data in children are limited. We conducted a systematic review on the efficacy/effectiveness and safety of TAF in infants,… read more here.

Keywords: safety; systematic review; adolescents living; effectiveness safety ... See more keywords
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Tenofovir alafenamide is associated with improved alanine aminotransferase and renal safety compared to tenofovir disoproxil fumarate

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27863

Abstract: Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir for the treatment of chronic hepatitis B (CHB) infection. We aimed to evaluate the impact of switching to TAF on alanine aminotransferase (ALT) normalization and renal… read more here.

Keywords: safety; alanine aminotransferase; renal safety; tenofovir disoproxil ... See more keywords
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The effect of depot medroxyprogesterone acetate on tenofovir alafenamide in rhesus macaques

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recommendations! Published in 2020 at "Antiviral research"

DOI: 10.1016/j.antiviral.2020.105001

Abstract: Prevention of HIV infection and unintended pregnancies are public health priorities. In sub-Saharan Africa, where HIV prevalence is highest, depot medroxyprogesterone acetate (DMPA) is widely used as contraception. Therefore, understanding potential interactions between DMPA and… read more here.

Keywords: tissue; depot medroxyprogesterone; tfv; dmpa ... See more keywords
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Analytical Lifecycle Management (ALM) and Analytical Quality by Design (AQbD) for analytical procedure development of related substances in tenofovir alafenamide fumarate tablets.

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recommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"

DOI: 10.1016/j.jpba.2021.114417

Abstract: Analytical procedure development for quantifying 10 impurities in Tenofovir Alafenamide Fumarate (TAF) tablets was a challenge for analytical and formulation researchers. The aim of this paper was to develop a robust, regulatory-flexible, application-specific Ultra Performance… read more here.

Keywords: procedure development; procedure; analytical procedure; tenofovir alafenamide ... See more keywords
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Switching from a regimen containing abacavir/lamivudine or emtricitabine/tenofovir disoproxil fumarate to emtricitabine/tenofovir alafenamide fumarate does not affect central nervous system HIV-1 infection

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recommendations! Published in 2019 at "Infectious Diseases"

DOI: 10.1080/23744235.2019.1670352

Abstract: Abstract Background: Despite suppressive antiretroviral therapy (ART), many HIV-infected individuals have low-level persistent immune activation in the central nervous system (CNS). There have been concerns regarding the CNS efficacy of tenofovir alafenamide fumarate (TAF) because… read more here.

Keywords: tenofovir; nervous system; central nervous; emtricitabine tenofovir ... See more keywords
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Switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide Significantly Worsens the Lipid Profile in a Real-World Setting.

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recommendations! Published in 2019 at "AIDS patient care and STDs"

DOI: 10.1089/apc.2019.0236

Abstract: Tenofovir disoproxil fumarate (TDF) has increasingly been replaced by tenofovir alafenamide (TAF) because of reduced kidney and bone toxicity with TAF. This switch has, however, caused worsening of lipid concentrations in clinical trials, but data… read more here.

Keywords: real world; disoproxil fumarate; cholesterol; tenofovir disoproxil ... See more keywords
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Why Are Patients Switching from Tenofovir Disoproxil Fumarate/Emtricitabine (Truvada) to Tenofovir Alafenamide/Emtricitabine (Descovy) for Pre-Exposure Prophylaxis?

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recommendations! Published in 2021 at "AIDS patient care and STDs"

DOI: 10.1089/apc.2021.0033

Abstract: Safety differences between tenofovir alafenamide/emtricitabine (TAF) and tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)-formulated pre-exposure prophylaxis (PrEP) appear to have little clinical significance for most PrEP users. Furthermore, generic TDF-formulated PrEP is projected to decrease the price of… read more here.

Keywords: prep; alafenamide emtricitabine; tenofovir disoproxil; descovy ... See more keywords
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Assessment of the greenness of new stability indicating micellar UPLC and HPTLC methods for determination of tenofovir alafenamide in dosage forms.

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recommendations! Published in 2021 at "Journal of chromatographic science"

DOI: 10.1093/chromsci/bmaa143

Abstract: In this study, a green stability indicating chromatographic methods were developed and validated for the quantitative determination of tenofovir alafenamide in the presence of its degradation products in bulk powder as well as in dosage… read more here.

Keywords: hptlc; stability indicating; dosage forms; micellar uplc ... See more keywords
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Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity

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recommendations! Published in 2018 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofy275

Abstract: Abstract Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous… read more here.

Keywords: tenofovir; multimorbid hiv; tenofovir alafenamide; infected patients ... See more keywords
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Tenofovir alafenamide and elvitegravir loaded nanoparticles for long-acting prevention of HIV-1 vaginal transmission: Erratum.

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recommendations! Published in 2019 at "AIDS"

DOI: 10.1097/01.aids.0000568920.95615.11

Abstract: The authors of this article [1] report an error in the description of the methods for the antiretroviral (ARV) drugs used in the pharmacokinetic (PK) study in mice. The mice in the PK study of… read more here.

Keywords: mice; alafenamide elvitegravir; elvitegravir loaded; tenofovir alafenamide ... See more keywords