Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01287h
Abstract: Poor tendon repair remains a clinical problem due to the difficulties in replicating the complex multiscale hierarchical structure of native tendons. In this work, a bioinspired fibrous scaffold with bimodal micro-nanofibers and a teno-inductive aligned… read more here.
Keywords: bimodal micro; progenitor cells; stem progenitor; micro nanofibrous ... See more keywords
Stem Cell Applications and Tenogenic Differentiation Strategies for Tendon Repair
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/3656498
Abstract: Tendons are associated with a high injury risk because of their overuse and age-related tissue degeneration. Thus, tendon injuries pose great clinical and economic challenges to the society. Unfortunately, the natural healing capacity of tendons… read more here.
Keywords: stem; tendon repair; tenogenic differentiation; stem cell ... See more keywords
Adipose-derived mesenchymal stem cells with hypoxic preconditioning improve tenogenic differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-021-02908-2
Abstract: Background Adipose-derived mesenchymal stem cells (ADSCs), as seed cells for tendon tissue engineering, are promising for tendon repair and regeneration. But for ADSCs, diverse oxygen tensions have different stimulatory effects. To explore this issue, we… read more here.
Keywords: differentiation; hif; mesenchymal stem; derived mesenchymal ... See more keywords
Electrospun aligned poly(ε-caprolactone) nanofiber yarns guiding 3D organization of tendon stem/progenitor cells in tenogenic differentiation and tendon repair
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.960694
Abstract: Hierarchical anisotropy structure directing 3D cellular orientation plays a crucial role in designing tendon tissue engineering scaffolds. Despite recent development of fabrication technologies for controlling cellular organization and design of scaffolds that mimic the anisotropic… read more here.
Keywords: structure; tendon tissue; tenogenic differentiation; stem progenitor ... See more keywords
Dexamethasone Is Not Sufficient to Facilitate Tenogenic Differentiation of Dermal Fibroblasts in a 3D Organoid Model
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DOI: 10.3390/biomedicines11030772
Abstract: Self-assembling three-dimensional organoids that do not rely on an exogenous scaffold but maintain their native cell-to-cell and cell-to-matrix interactions represent a promising model in the field of tendon tissue engineering. We have identified dermal fibroblasts… read more here.
Keywords: dermal fibroblasts; cell; tenogenic differentiation; dex ... See more keywords
3D Bioprinting of Human Adipose-Derived Stem Cells and Their Tenogenic Differentiation in Clinical-Grade Medium
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21228694
Abstract: Defining the best combination of cells and biomaterials is a key challenge for the development of tendon tissue engineering (TE) strategies. Adipose-derived stem cells (ASCs) are ideal candidates for this purpose. In addition, controlled cell-based… read more here.
Keywords: tenogenic differentiation; derived stem; differentiation; stem cells ... See more keywords
Platelet-Derived Extracellular Vesicles Promote Tenogenic Differentiation of Stem Cells on Bioengineered Living Fibers
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043516
Abstract: Tendon mimetic scaffolds that recreate the tendon hierarchical structure and niche have increasing potential to fully restore tendon functionality. However, most scaffolds lack biofunctionality to boost the tenogenic differentiation of stem cells. In this study,… read more here.
Keywords: tenogenic differentiation; differentiation stem; living fibers; platelet derived ... See more keywords