Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins
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DOI: 10.1007/s10522-018-09792-0
Abstract: Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing;… read more here.
Keywords: cell senescence; inhibition; senescence; tenovin ... See more keywords