Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.
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DOI: 10.1016/j.devcel.2018.03.011
Abstract: We sought to understand how cells collectively elongate epithelial tubes. We first used 3D culture and biosensor imaging to demonstrate that epithelial cells enrich Ras activity, phosphatidylinositol (3,4,5)-trisphosphate (PIP3), and F-actin to their leading edges… read more here.
Keywords: tension; tube elongation; tension dynamics; interfacial tension ... See more keywords