Molecular Tension Probes to Investigate the Mechanopharmacology of Single Cells: A Step toward Personalized Mechanomedicine
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800069
Abstract: Given that dysregulation of mechanics contributes to diseases ranging from cancer metastasis to lung disease, it is important to develop methods for screening the efficacy of drugs that target cellular forces. Here, nanoparticle-based tension sensors… read more here.
Keywords: probes investigate; mechano ec50; mechanopharmacology; molecular tension ... See more keywords
Exploring Integrin-Mediated Force Transmission during Confined Cell Migration by DNA-Based Tension Probes.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04962
Abstract: Mechanical forces have profound effects on the morphology and migration of cells in a two-dimensional environment. However, cells in vivo mostly migrate in three-dimensional space while physically constrained, and the mechanism by which cellular dynamic… read more here.
Keywords: based tension; tension probes; migration; tension ... See more keywords
Programmable Multivalent DNA-Origami Tension Probes for Reporting Cellular Traction Forces.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b01374
Abstract: Mechanical forces are central to most, if not all, biological processes, including cell development, immune recognition, and metastasis. Because the cellular machinery mediating mechano-sensing and force generation is dependent on the nanoscale organization and geometry… read more here.
Keywords: origami tension; dna origami; tension probes; force ... See more keywords
Molecular Tension Probes to Quantify Cell-Generated Mechanical Forces
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2049
Abstract: Living cells generate, sense, and respond to mechanical forces through their interaction with neighboring cells or extracellular matrix, thereby regulating diverse cellular processes such as growth, motility, differentiation, and immune responses. Dysregulation of mechanosensitive signaling… read more here.
Keywords: tension probes; generated mechanical; mechanical forces; tension ... See more keywords