Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity
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DOI: 10.3389/fendo.2022.945030
Abstract: Male sex determination in mammals is initiated by SRY, a Y-encoded transcription factor. The protein contains a high-mobility-group (HMG) box mediating sequence-specific DNA bending. Mutations causing XY gonadal dysgenesis (Swyer syndrome) cluster in the box… read more here.
Keywords: swyer syndrome; tenuous transcriptional; threshold; sex determination ... See more keywords