Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3415-5
Abstract: Dear Editor, Inherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of genetic blood disorders in which there is usually some form of aplastic anemia, associatedwith a family history of the same disorder. In… read more here.
Keywords: aplastic anemia; anemia; terc variant; terc ... See more keywords
Common variants of human TERT and TERC genes and susceptibility to sporadic Alzheimers disease
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2016.12.017
Abstract: &NA; Studies investigating telomere length in association with cognitive decline, dementia, and sporadic Alzheimer's disease (AD) have frequently found shorter telomeres to be associated with the development of AD and telomerase expression with pathological processes… read more here.
Keywords: telomerase; susceptibility; common variants; telomere length ... See more keywords
HuR regulates telomerase activity through TERC methylation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04617-7
Abstract: Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates… read more here.
Keywords: methylation; telomerase activity; hur regulates; terc ... See more keywords
Urinary Exosomal Long Noncoding RNA TERC as a Noninvasive Diagnostic and Prognostic Biomarker for Bladder Urothelial Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/9038808
Abstract: Purpose Bladder cancer is one of the most common urological malignancies worldwide, and approximately 90% of bladder cancer cases are histologically typed as bladder urothelial carcinoma (BLCA). Exosomes are 30 to 200 nm extracellular vesicles that… read more here.
Keywords: bladder urothelial; prognostic biomarker; terc; urinary exosomal ... See more keywords
TERC Stimulates Fatty Acid Metabolism to Promote Bladder Cancer Progression.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-3439
Abstract: Muscle-invasive bladder cancer is susceptible to metastasis and has a poor prognosis. A better understanding of the biological process and molecular mechanisms associated with bladder cancer aggressiveness could lead to the development of effective strategies… read more here.
Keywords: cancer; acid metabolism; terc; bladder cancer ... See more keywords
Genomic amplification of HPV, h-TERC and c-MYC in liquid-based cytological specimens for screening of cervical intraepithelial neoplasia and cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2018.9825
Abstract: Cervical cancer is one of the most prevalent female cancer types in developing countries. ThinPrep cytological test (TCT) and human papillomavirus (HPV) detection are canonical screening methods for cervical cancer currently. However, there are limitations… read more here.
Keywords: histopathology; screening cervical; terc; hpv ... See more keywords
Telomerase RNA component knockout exacerbates Staphylococcus aureus pneumonia by extensive inflammation and dysfunction of T cells
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.100433
Abstract: The telomerase RNA component (Terc) constitutes a non-coding RNA critical for telomerase function, commonly associated with aging and pivotal in immunomodulation during inflammation. Our study unveils heightened susceptibility to pneumonia caused by Staphylococcus aureus (S.… read more here.
Keywords: telomerase rna; rna component; knockout; terc ... See more keywords