Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0475-8
Abstract: Background Therapeutic hypothermia is partially protective for neonatal hypoxic–ischemic encephalopathy (HIE). Damage to the white matter tracts is highly associated with adverse outcomes after HIE, but the effectiveness and optimal duration of hypothermia to attenuate… read more here.
Keywords: term fetal; hypothermia; near term; cerebral hypothermia ... See more keywords
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
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DOI: 10.1186/s12974-021-02238-4
Abstract: Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administration would attenuate… read more here.
Keywords: term fetal; term; near term; inflammation ... See more keywords
Therapeutic Hypothermia Attenuates Cortical Interneuron Loss after Cerebral Ischemia in Near-Term Fetal Sheep
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DOI: 10.3390/ijms24043706
Abstract: Therapeutic hypothermia significantly improves outcomes after neonatal hypoxic-ischemic (HI) encephalopathy but is only partially protective. There is evidence that cortical inhibitory interneuron circuits are particularly vulnerable to HI and that loss of interneurons may be… read more here.
Keywords: near term; survival; interneuron; hypothermia ... See more keywords