Determining the Role of N-Terminal Acetylation on α-Synuclein Function
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1982
Abstract: α-Synuclein (αS) is an abundant neuronal protein implicated in Parkinson's disease. Acetylation of the N-terminal methionine of αS is a ubiquitous modification of αS derived from healthy brain tissue as well as from Parkinson's disease… read more here.
Keywords: role terminal; acetylation; synuclein; terminal acetylation ... See more keywords
Molecular mechanism of N-terminal acetylation by the ternary NatC complex.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.05.003
Abstract: Protein N-terminal acetylation is predominantly a ribosome-associated modification, with NatA-E serving as the major enzymes. NatC is the most unusual of these enzymes, containing one Naa30 catalytic subunit and two auxiliary subunits, Naa35 and Naa38;… read more here.
Keywords: mechanism terminal; acetylation; terminal acetylation; natc complex ... See more keywords
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2020.08.005
Abstract: N-terminal acetylation (NTA) is one of the most widespread protein modifications, which occurs on most eukaryotic proteins, but is significantly less common on bacterial and archaea proteins. This modification is carried out by a family… read more here.
Keywords: protein terminal; acetylation; mechanism; terminal acetylation ... See more keywords
Kinetic Analysis of the Effect of N-Terminal Acetylation on Thymine DNA Glycosylase.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00823
Abstract: Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases. TDG contains a long, unstructured… read more here.
Keywords: effect terminal; acetylation; dna; dna glycosylase ... See more keywords
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00104
Abstract: Parkinson’s disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since α-synuclein is constitutively N-terminally… read more here.
Keywords: terminal acetylation; aggregation; synuclein; aggregation process ... See more keywords
N-Terminal Acetylation Preserves α-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00250
Abstract: The abnormal aggregation of α-synuclein (α-Syn) is closely associated with Parkinson's disease. Different post-translational modifications of α-Syn have been identified and contribute distinctly in α-Syn aggregation and cytotoxicity. Recently, α-Syn was reported to be N-terminally… read more here.
Keywords: oligomerization; hydrogen bonds; intermolecular hydrogen; terminal acetylation ... See more keywords
Cellular effects of NAT-mediated histone N-terminal acetylation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260801
Abstract: Histone acetylation involves the addition of acetyl groups to specific amino acid residues. This chemical histone modification is broadly divided into two types - acetylation of the amino group found on the side chain of… read more here.
Keywords: acetylation; effects nat; histone terminal; cellular effects ... See more keywords
NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17332
Abstract: The identification of new targets for systemic therapy of hepatocellular carcinoma (HCC) is an urgent medical need. Recently, we showed that hNatB catalyzes the N-α-terminal acetylation of 15% of the human proteome and that this… read more here.
Keywords: hepatocellular carcinoma; actin cytoskeleton; acetylation; target ... See more keywords
Up-regulation of ubiquitin-proteasome activity upon loss of NatA-dependent N-terminal acetylation.
Sign Up to like & getrecommendations! Published in 2022 at "Life science alliance"
DOI: 10.26508/lsa.202000730
Abstract: N-terminal acetylation is a prominent protein modification, and inactivation of N-terminal acetyltransferases (NATs) cause protein homeostasis stress. Using multiplexed protein stability profiling with linear ubiquitin fusions as reporters for the activity of the ubiquitin proteasome… read more here.
Keywords: acetylation; terminal acetylation; regulation ubiquitin; activity ... See more keywords