Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels
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DOI: 10.1038/s41598-019-55232-5
Abstract: There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable… read more here.
Keywords: terminal adpr; adpr; binding pocket; adpr binding ... See more keywords