Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells
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DOI: 10.1002/cbic.202000026
Abstract: Conformational changes in α‐synuclein (α‐syn) are central to its biological function and Parkinson's disease pathology. Here, terminal alkynes (homopropargylglycine) were employed as environmentally sensitive Raman probes at residues 1, 5, 116, and 127 to characterize… read more here.
Keywords: solution cells; terminal alkynes; probes synuclein; raman probes ... See more keywords
Palladium‐Catalyzed Dehydrogenative Coupling Reaction of Terminal Alkynes with Unactivated Alkenes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700268
Abstract: Terminal alkynes having a bulky substituent dehydrogenatively couple with unactivated terminal alkenes with catalysis of palladium. The terminal sp carbon forms a bond with the internal sp2 carbon of the alkene regioselectively to produce branched,… read more here.
Keywords: catalyzed dehydrogenative; reaction terminal; coupling reaction; terminal alkynes ... See more keywords
Copper(0) Nanoparticles Supported on Al2O3 as Catalyst for Carboxylation of Terminal Alkynes
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Letters"
DOI: 10.1007/s10562-017-2127-0
Abstract: The copper particles, supported on Al2O3 were for the first time used as heterogeneous, highly active, easily available, and recyclable copper catalyst of direct carboxylation of various terminal alkynes with CO2 (2 bar) in the presence… read more here.
Keywords: supported al2o3; terminal alkynes; copper nanoparticles; catalyst ... See more keywords
One-pot synthesis of 3-arylaminomaleimides from terminal alkynes and isocyanates
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.03.050
Abstract: The reaction of aryl acetylide anions with phenyl isocyanate and subsequent addition of a protonating agent such as ethanol affords good yields of 3-aminomaleimides, formed by the cyclization of one molecule of alkyne with two… read more here.
Keywords: pot synthesis; terminal alkynes; synthesis arylaminomaleimides; arylaminomaleimides terminal ... See more keywords
Ruthenium hydride catalyzed silylvinylation of terminal alkynes under ethylene atmosphere at 80 psi
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.09.023
Abstract: The development of methods for the stereoselective synthesis of polysubstituted 1,3-dienes is a challenge to synthetic chemistry. Herein is reported a selective approach for the synthesis of polysubstituted 1,3-dienes using the ruthenium hydride catalyzed intramolecular… read more here.
Keywords: catalyzed silylvinylation; ruthenium hydride; terminal alkynes; hydride catalyzed ... See more keywords
Iodination of terminal alkynes using KI/CuSO4 – A facile method with potential for radio-iodination
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.02.041
Abstract: Graphical abstract Herein, we report an efficient new method for iodination of terminal alkynes using stoichiometric KI and CuSO4 in acetate buffer that holds promise for further development into a method for radio-iodination. read more here.
Keywords: iodination; iodination terminal; terminal alkynes; method ... See more keywords
Cyclocarbonylation-Iodination of terminal alkynes with ketones and ICl via 1,2-migration
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152374
Abstract: Abstract A simple, three-component, one-pot, room-temperature reaction of cyclocarbonylation-iodination is developed from terminal alkynes, ketones, and ICl. The reaction proceeds through the formation of 3°-propargyl alcohols and a subsequent 1,2-shift lead to the formation of… read more here.
Keywords: ketones icl; alkynes ketones; cyclocarbonylation iodination; iodination terminal ... See more keywords
DNA Compatible Oxidization and Amidation of Terminal Alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00340
Abstract: Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid-amine reagents can be transformed directly to the respective… read more here.
Keywords: amidation terminal; dna compatible; compatible oxidization; terminal alkynes ... See more keywords
Copper-Catalyzed Disulfonation of Terminal Alkynes with Sodium Arylsulfinates.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00575
Abstract: A novel and direct disulfonylation reaction of commercially available terminal alkynes under copper(I)/bromodifluoroacetate cocatalyst has been realized. This protocol provides a facile and practical pathway to selectively access (E)-1,2-disulfonylethenes, in which features good functional group… read more here.
Keywords: catalyzed disulfonation; copper catalyzed; terminal alkynes; alkynes sodium ... See more keywords
Copper-Catalyzed 1,1-Boroalkylation of Terminal Alkynes: Access to Alkenylboronates via a Three-Component Reaction.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01081
Abstract: A copper-catalyzed three-component reaction of terminal alkynes, diazo compounds, and B2pin2 to prepare trisubstituted alkenylboronates has been developed. This difunctionalization of alkynes selectively occurs at the terminal carbon atom and proceeds via a tandem sequence.… read more here.
Keywords: copper; terminal alkynes; three component; component reaction ... See more keywords
Hydrogen-Bonding Controlled Nickel-Catalyzed Regioselective Cyclotrimerization of Terminal Alkynes.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01095
Abstract: Herein we report a hydrogen-bonding controlled nickel-catalyzed regioselective cyclotrimerization of terminal alkynes in moderate to excellent yields with high regioselectivities toward 1,3,5-trisubstituted benzenes. This method features a cheap catalyst, mild reaction conditions, and excellent functional… read more here.
Keywords: controlled nickel; bonding controlled; terminal alkynes; hydrogen bonding ... See more keywords