A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition
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DOI: 10.1016/j.biopsych.2019.04.026
Abstract: BACKGROUND The ɛ4 isoform of apolipoprotein E (apoE4) is a major genetic risk factor for the development of sporadic Alzheimer's disease (AD), and its modification has been an intense focus for treatment of AD during… read more here.
Keywords: precursor protein; pathology; amyloid precursor; interaction ... See more keywords