Phosphorylation-mediated disassembly of C-terminal binding protein 2 tetramer impedes epigenetic silencing of pluripotency in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae1076
Abstract: Abstract Cells need to overcome both intrinsic and extrinsic threats. Although pluripotency is associated with damage responses, how stem cells respond to DNA damage remains controversial. Here, we elucidate that DNA damage activates Chk2, leading… read more here.
Keywords: phosphorylation; pluripotency; stem cells; terminal binding ... See more keywords
Combination of two monoclonal antibodies with SOCS1 N‐ and C‐terminal binding sites to address SOCS1 status in B cells and B‐cell lymphoma
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DOI: 10.1111/ejh.13730
Abstract: Accumulating studies show that the tumour suppressor SOCS1 is one of the most frequently mutated genes in lymphomas, often affecting the coding sequence of SOCS1 protein. Depending on the type of mutation and lymphoma concerned,… read more here.
Keywords: antibodies socs1; combination two; two monoclonal; terminal binding ... See more keywords
Role of C terminal binding proteins (CtBP) in pancreatic adenocarcinoma (PDAC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.320
Abstract: 320Background: Overexpression of the oncogenic transcription factors CtBP1 and 2 is common and associated with poor prognosis in ovarian, breast and prostate cancer. CtBP2 drives tumor progression through promotion of epithelial-mesenchymal transition (EMT) and cancer… read more here.
Keywords: role terminal; binding proteins; pdac; proteins ctbp ... See more keywords