Articles with "terminal bromodomains" as a keyword



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Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.

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Published in 2020 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.0c00566

Abstract: The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromodomains of… read more here.

Keywords: anti inflammatory; extraterminal domain; inflammatory antiproliferative; domain bet ... See more keywords