Terminal differentiation of keratinocytes was damaged in type 2 diabetic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07367-4
Abstract: AIMS Although skin manifestations are common in diabetic patients, its characteristics are poorly identified. This study explored the differentiation process of keratinocytes in type 2 diabetes mellitus (T2DM) in vivo. METHODS Back skin of T2DM… read more here.
Keywords: differentiation; keratinocytes damaged; differentiation keratinocytes; terminal differentiation ... See more keywords
Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.07.034
Abstract: Summary The rapid transit from hypoxia to normoxia in the lung that follows the first breath in newborn mice coincides with alveolar macrophage (AM) differentiation. However, whether sensing of oxygen affects AM maturation and function… read more here.
Keywords: terminal differentiation; alveolar macrophage; self renewal; mice ... See more keywords
AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.026
Abstract: The developmental mechanisms that orchestrate differentiation of specific nephron segments are incompletely understood, and the factors that maintain their terminal differentiation after nephrogenesis remain largely unknown. Here, the transcription factor AP-2β is shown to be… read more here.
Keywords: terminal differentiation; kctd1; renal fibrosis; differentiation ... See more keywords
Centrosome Reduction Promotes Terminal Differentiation of Human Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.08.007
Abstract: Summary Centrosome reduction and redistribution of pericentriolar material (PCM) coincides with cardiomyocyte transitions to a post-mitotic and matured state. However, it is unclear whether centrosome changes are a cause or consequence of terminal differentiation. We… read more here.
Keywords: reduction promotes; terminal differentiation; centrosome reduction;
Trynity models a tube valve in the Drosophila larval airway system.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.02.019
Abstract: Terminal differentiation of an organ is the last step in development that enables the organism to survive in the outside world after birth. Terminal differentiation of the insect tracheae that ends with filling the tubular… read more here.
Keywords: drosophila; terminal differentiation; trynity models; system ... See more keywords
Photoredox-Catalyzed Decarboxylative C-Terminal Differentiation for Bulk- and Single-Molecule Proteomics.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00631
Abstract: Methods for the selective labeling of biogenic functional groups on peptides are being developed and used in the workflow of both current and emerging proteomics technologies, such as single-molecule fluorosequencing. To achieve successful labeling with… read more here.
Keywords: molecule; single molecule; terminal differentiation; catalyzed decarboxylative ... See more keywords
Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-00324-9
Abstract: Molecular mechanisms underlying luteinization (terminal differentiation of granulosa and theca cells after ovulation) and luteolysis (demise of corpus luteum) are poorly understood in human ovary. Here we report that activin-A, after binding to its cognate… read more here.
Keywords: granulosa cells; terminal differentiation; granulosa; jnk pathway ... See more keywords
Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08947-2
Abstract: After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation and centrosome disassembly, rendering the heart unable to regenerate. Yet, it has been suggested that newborn mammals regenerate their hearts after apical resection by cardiomyocyte proliferation.… read more here.
Keywords: newborn mammalian; terminal differentiation; heart; apical resection ... See more keywords
Bone morphogenetic protein‐4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology Research"
DOI: 10.1111/hepr.12823
Abstract: Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein‐4 (BMP‐4) is essential for… read more here.
Keywords: fetal hepatic; proliferation terminal; terminal differentiation; hepatic stem ... See more keywords
Abstract 1595: Thyroid hormone drives the terminal differentiation of tumor cells in medulloblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1595
Abstract: Hypothyroidism is commonly detected in patients with medulloblastoma (MB), a pediatric brain tumor, which is generally considered as a treatment-related complication. Although reduced levels of thyroid hormone (TH) significantly correlate with poor survival of patients… read more here.
Keywords: differentiation tumor; tumor cells; thyroid hormone; differentiation ... See more keywords
Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000378
Abstract: During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0 in which they are refractory to mitogenic signals. Entry into G0 is usually initiated through the repression of… read more here.
Keywords: cycle exit; cell; terminal differentiation; cell cycle ... See more keywords