Molecular insights into RNA recognition by the ZAR1 C‐terminal domain
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DOI: 10.1002/1873-3468.70080
Abstract: Zygote arrested‐1 (ZAR1)‐dependent translational repression plays an important role during early oogenesis. Here, we solved the crystal structure of the C‐terminal domain of ZAR1, which contains three zinc‐binding motifs, and confirmed its ability to bind… read more here.
Keywords: zar1; insights rna; zar1 terminal; terminal domain ... See more keywords
Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
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DOI: 10.1002/2211-5463.70038
Abstract: Polymorphic toxins (PT) are multidomain proteins used for interbacterial competition and pathogenesis. The N‐terminal domain of PT specifies the mode of transport and names the family, while the variable C‐terminal domain carries the toxic activity,… read more here.
Keywords: pyrophosphokinase domains; polymorphic toxins; terminal domain; adenosine pyrophosphokinase ... See more keywords
N‐terminal domain of SARS CoV‐2 spike protein mutation associated reduction in effectivity of neutralizing antibody with vaccinated individuals
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27181
Abstract: Dear Editor The spike (S) protein is a homotrimer on the SARS‐CoV‐2 surface which targets the angiotensin‐converting enzyme‐2 in humans (ACE2). The Spike (S) coronavirus 2 (SARS‐CoV‐2) protein is a major driving force for viral… read more here.
Keywords: protein; terminal domain; cov spike; spike protein ... See more keywords
In vitro and in vivo suppression of SARS‐CoV‐2 replication by a modified, short, cell‐penetrating peptide targeting the C‐terminal domain of the viral spike protein
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28626
Abstract: Peptides are promising therapeutic agents for COVID‐19 because of their specificity, easy synthesis, and ability to be fine‐tuned. We previously demonstrated that a cell‐permeable peptide corresponding to the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)… read more here.
Keywords: cell; spike; replication; terminal domain ... See more keywords
Identification of a conserved N‐terminal domain in the first module of ACV synthetases
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DOI: 10.1002/mbo3.1145
Abstract: The l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β‐lactams. The enzyme has been extensively characterized in terms of tripeptide formation and substrate specificity.… read more here.
Keywords: terminal domain; conserved terminal; first module; domain first ... See more keywords
Crystal structure of the trimeric N‐terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3418
Abstract: Centrin is a member of the EF‐hand superfamily of calcium‐binding proteins, a highly conserved eukaryotic protein that binds to Ca2+. Its self‐assembly plays a causative role in the fiber contraction that is associated with the… read more here.
Keywords: crystal structure; terminal domain; domain ciliate; centrin ... See more keywords
Deletion of the N‐terminal domain of the yeast vacuolar (Na+,K+)/H+ antiporter Vnx1p improves salt tolerance in yeast and transgenic Arabidopsis
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DOI: 10.1002/yea.3450
Abstract: Cation/proton antiporters play a major role in the control of cytosolic ion concentrations in prokaryotes and eukaryotes organisms. In yeast, we previously demonstrated that Vnx1p is a vacuolar monovalent cation/H+ exchanger showing Na+/H+ and K+/H+… read more here.
Keywords: terminal domain; tolerance; antiporter; yeast ... See more keywords
N-terminal domain of the RNA polymerase of very virulent infectious bursal disease virus contributes to viral replication and virulence
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DOI: 10.1007/s11427-017-9297-8
Abstract: Infectious bursal disease virus (IBDV) causes an economically significant disease of chickens worldwide (Berg, 2000). The molecular basis for the virulence of very virulent IBDV (vvIBDV) is not fully understood. Previous studies have shown that… read more here.
Keywords: viral replication; terminal domain; vvibdv; virulence ... See more keywords
1H, 15N, 13C backbone resonance assignment of the C-terminal domain of enzyme I from Thermoanaerobacter tengcongensis
Sign Up to like & getrecommendations! Published in 2018 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9788-x
Abstract: Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of… read more here.
Keywords: backbone resonance; terminal domain; thermoanaerobacter tengcongensis; 15n 13c ... See more keywords
NMR 1H, 13C, 15N backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-018-9840-5
Abstract: The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated proteins in eukaryotic cells. It consists of a 20S barrel-shaped core particle capped by two 19S regulatory particle at both ends. The Rpn5… read more here.
Keywords: terminal domain; 13c 15n; proteasome; subunit ... See more keywords
1H, 13C and 15N chemical shift assignments of the C-terminal domain of human UDP-Glucuronosyltransferase 2B7 (UGT2B7-C).
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecular NMR assignments"
DOI: 10.1007/s12104-021-10024-9
Abstract: The human UDP-glucuronosyltransferase (UGT) family of enzymes catalyze the covalent addition of glucuronic acid to a wide range of compounds, generally rendering them inactive. Although important for clearance of environmental toxins and metabolites, UGT activation… read more here.
Keywords: 13c 15n; human udp; terminal domain; udp glucuronosyltransferase ... See more keywords