The N‐terminal domains of the paralogous HycE and NuoCD govern assembly of the respective formate hydrogenlyase and NADH dehydrogenase complexes
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12787
Abstract: Formate hydrogenlyase (FHL) is the main hydrogen‐producing enzyme complex in enterobacteria. It converts formate to CO2 and H2 via a formate dehydrogenase and a [NiFe]‐hydrogenase. FHL and complex I are evolutionarily related and share a… read more here.
Keywords: terminal domains; dehydrogenase; formate hydrogenlyase; domains paralogous ... See more keywords
The NMDA receptor intracellular C‐terminal domains reciprocally interact with allosteric modulators
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.11.018
Abstract: &NA; N‐methyl‐D‐aspartate receptors (NMDARs) have multiple prominent roles in CNS function but their excessive or insufficient activity contributes to neuropathological/psychiatric disorders. Consequently, a variety of positive and negative allosteric modulators (PAMs and NAMs, respectively) have… read more here.
Keywords: terminal domains; allosteric modulators; intracellular terminal; pam activity ... See more keywords
C-Terminal Domains of Spider Silk Proteins Having Divergent Structures but Conserved Functional Roles.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01513
Abstract: Spider silk is self-assembled from silk proteins or spidroins. C-terminal domains (CTDs) of various types of spidroins are relatively conserved in amino acid sequences and are suggested to adopt similar structures and perform similar functional… read more here.
Keywords: terminal domains; spider silk; silk proteins; silk ... See more keywords
Conformational Stability and Interplay of Helical N- and C-Terminal Domains with Implications on Major Ampullate Spidroin Assembly.
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DOI: 10.1021/acs.biomac.6b01713
Abstract: Major ampullate spidroin (MaSp) assembly starts in the abdomen of the spider, where spidroins are stored as a liquid dope at a high concentration. The dope is squeezed into the spinning duct, and assembly is… read more here.
Keywords: terminal domains; major ampullate; spidroin; spidroin assembly ... See more keywords
Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0587-z
Abstract: Pathogenic bacteria such as Escherichia coli assemble surface structures termed pili, or fimbriae, to mediate binding to host-cell receptors1. Type 1 pili are assembled via the conserved chaperone–usher pathway2–5. The outer-membrane usher FimD recruits pilus… read more here.
Keywords: terminal domains; terminal domain; growing pilus; outer membrane ... See more keywords
RMI1 and TOP3α limit meiotic CO formation through their C-terminal domains
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1210
Abstract: Abstract At meiosis, hundreds of programmed DNA double-strand breaks (DSBs) form and are repaired by homologous recombination. From this large number of DSBs, only a subset yields crossovers (COs), with a minimum of one CO… read more here.
Keywords: terminal domains; limit; recombination intermediates; recombination ... See more keywords
C‐terminal domains of bacterial proteases: structure, function and the biotechnological applications
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DOI: 10.1111/jam.13317
Abstract: C‐terminal domains widely exist in the C‐terminal region of multidomain proteases. As a β‐sandwich domain in multidomain protease, the C‐terminal domain plays an important role in proteolysis including regulation of the secretory process, anchoring and… read more here.
Keywords: terminal domains; proteases structure; domains bacterial; bacterial proteases ... See more keywords
Contributions of the N- and C-Terminal Domains of Initiation Factor 3 to Its Functions in the Fidelity of Initiation and Antiassociation of the Ribosomal Subunits
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00051-17
Abstract: ABSTRACT Initiation factor 3 (IF3) is one of the three conserved prokaryotic translation initiation factors essential for protein synthesis and cellular survival. Bacterial IF3 is composed of a conserved architecture of globular N- and C-terminal… read more here.
Keywords: terminal domains; fidelity; initiation; initiation factor ... See more keywords
New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies
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DOI: 10.3390/ijms23031613
Abstract: In this work, we performed a comparative study of the formation of PML bodies by full-length PML isoforms and their C-terminal domains in the presence and absence of endogenous PML. Based on the analysis of… read more here.
Keywords: terminal domains; pml; endogenous pml; formation pml ... See more keywords