In silico studies of interactions of peptide-conjugated cholesterol metabolites and betulinic acid with EGFR, LDR, and N-terminal fragment of CCKA receptors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-021-05007-5
Abstract: In this work, we designed three new ligands by conjugating cholesterol metabolites 3-hydroxy-5-cholestenoic acid (3-HC) and 3-oxo-4-cholestenoic acid (3-OC) and the natural tri-terpenoid betulinic acid with the tumor-targeting peptide YHWYGYTPQNVI. Molecular interactions with the unconjugated… read more here.
Keywords: betulinic acid; cholesterol metabolites; acid; ccka ... See more keywords
Lipid Bilayer Interactions of Amyloidogenic N-Terminal Fragment of Apolipoprotein A-I Probed by Förster Resonance Energy Transfer and Molecular Dynamics Simulations
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DOI: 10.1007/s10895-018-2267-7
Abstract: The effects of one of the amyloidogenic mutations of apolipoprotein A-I (apoA-I), G26R, on the thermal stability, structural dynamics and lipid-associating properties of the 1–83 N-terminal fragment of apoA-I (A83) have been investigated using the Förster… read more here.
Keywords: energy transfer; molecular dynamics; rster resonance; terminal fragment ... See more keywords
The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210809119
Abstract: Significance The negative feedback system that tempers inflammasome activation and downstream inflammation remains unknown. To date, there has been intensive study of the role of Gasdermin D as a central player in executing pyroptosis, the… read more here.
Keywords: negative feedback; feedback system; activation; terminal fragment ... See more keywords
Protection against β‐amyloid neurotoxicity by a non‐toxic endogenous N‐terminal β‐amyloid fragment and its active hexapeptide core sequence
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14257
Abstract: High levels (μM) of beta amyloid (Aβ) oligomers are known to trigger neurotoxic effects, leading to synaptic impairment, behavioral deficits, and apoptotic cell death. The hydrophobic C‐terminal domain of Aβ, together with sequences critical for… read more here.
Keywords: hexapeptide core; core sequence; terminal fragment; fragment active ... See more keywords
Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063137
Abstract: Signal peptides (SPs) not only mediate targeting to the endoplasmic reticulum (ER) but also play important roles as biomarkers and substances with physiological activity in extracellular fluids including blood. SPs are thought to be degraded… read more here.
Keywords: extracellular fluid; sequence; sequence dependent; protein ... See more keywords