The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring
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DOI: 10.1002/2211-5463.13565
Abstract: The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding. Crystallographic studies have revealed the… read more here.
Keywords: terminal half; rad52 protein; structure; cryo ... See more keywords
Revised terminal half‐life of nonacog alfa as derived from extended sampling data: A real‐world study involving 64 haemophilia B patients on nonacog alfa regular prophylaxis
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DOI: 10.1111/hae.14560
Abstract: Nonacog alfa, a standard half‐life recombinant factor IX (FIX), is used as a prophylactic treatment in severe haemophilia B (SHB) patients. Its half‐life determined in clinical studies involving a limited sampling (72 h) was shown… read more here.
Keywords: half life; terminal half; nonacog alfa; revised terminal ... See more keywords
A 77 Amino Acid Region in the N-Terminal Half of the HSV-1 E3 Ubiquitin Ligase ICP0 Contributes to Counteracting an Established Type 1 Interferon Response
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DOI: 10.1128/spectrum.00593-22
Abstract: Interferons (IFNs) are secreted cellular factors that are induced by viral infection and limit replication. HSV-1 is largely refractory to the antiviral effects of type 1 IFNs, which are synthesized shortly after viral infection, in… read more here.
Keywords: terminal half; region; hsv; ifn ... See more keywords
SAT-040 Structural Mechanisms of Parathyroid Hormone (PTH) Binding to Receptor and Regulation of Endosomal Signaling
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DOI: 10.1210/js.2019-sat-040
Abstract: Abstract The parathyroid hormone (PTH) type 1 receptor (PTHR) is a key regulator of bone turnover and calcium homeostasis. PTHR primarily activates the stimulatory G-protein, Gs, for adenylate cyclases that induce the production of cAMP.… read more here.
Keywords: terminal half; hinge; pth; receptor ... See more keywords