In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2044977
Abstract: ABSTRACT N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically to address miscleavage issues.… read more here.
Keywords: terminal heterogeneity; signal peptides; high throughput; miscleavage ... See more keywords
N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease
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DOI: 10.1111/nan.12637
Abstract: The deposition of amyloid‐β (Aβ) peptides in the form of extracellular plaques in the brain represents one of the classical hallmarks of Alzheimer’s disease (AD). In addition to ‘full‐length’ Aβ starting with aspartic acid (Asp‐1),… read more here.
Keywords: amyloid; alzheimer disease; heterogeneity parenchymal; vascular amyloid ... See more keywords