Asparaginyl Endopeptidase-Mediated Protein C-Terminal Hydrazinolysis for the Synthesis of Bioconjugates.
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DOI: 10.1021/acs.bioconjchem.1c00551
Abstract: Asparaginyl endopeptidases (AEPs) are cysteinyl enzymes naturally catalyzing the hydrolysis and transpeptidation reactions at Asx-Xaa bonds. These reactions go by a common acyl-enzyme thioester intermediate, which is either attacked by water (for a protease-AEP) or… read more here.
Keywords: endopeptidase mediated; protein terminal; terminal hydrazinolysis; mediated protein ... See more keywords