Safety, Pharmacokinetics, and Pharmacodynamics of CC‐90001 (BMS‐986360), a c‐Jun N‐terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants
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DOI: 10.1002/cpdd.1178
Abstract: CC‐90001 selectively inhibits c‐Jun N‐terminal kinase (JNK), a stress‐activated protein implicated in fibrosis. In 3 phase 1 trials evaluating CC‐90001 pharmacokinetics, pharmacodynamics, and safety, healthy adults (N = 184) received oral CC‐90001 in a single… read more here.
Keywords: safety; pharmacokinetics pharmacodynamics; jun terminal; phase ... See more keywords
The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_43
Abstract: c-Jun N-terminal kinase (JNK), a member of stress-induced mitogen-activated protein (MAP) kinase family, has been shown to modulate a variety of biological processes associated with neurodegenerative pathology of the retina. In particular, various retinal cell… read more here.
Keywords: jnk; jun terminal; kinase jnk; terminal kinase ... See more keywords
Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105916
Abstract: BACKGROUND Asthma is closely associated with tobacco smoking (TS) and is more difficult to effectively treat after exposure to TS. OBJECTIVE To observe the effects of TS on the expression of endothelin-2 (ET-2) and airway… read more here.
Keywords: amino terminal; tobacco smoking; inflammation; airway inflammation ... See more keywords
Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.
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DOI: 10.1021/acs.jmedchem.6b01180
Abstract: The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3) was successfully transferred to our well validated pyridinylimidazole scaffold varying several structural features in order to deduce crucial structure-activity relationships. Joint targeting of the… read more here.
Keywords: pyridinylimidazoles covalent; jun terminal; tri tetrasubstituted; tetrasubstituted pyridinylimidazoles ... See more keywords
FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
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DOI: 10.1038/s41598-017-02318-7
Abstract: FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated. Autophagy has a protective… read more here.
Keywords: jnk; jun terminal; terminal kinase; fk866 ... See more keywords
Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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DOI: 10.1101/2022.02.18.481032
Abstract: The design of a constitutively active form of the C-terminal kinase domain of the p90 ribosomal S6 kinase 2 (RSK2) is described, and this is based on a phosphomimetic mutation and a C-terminal truncation, yielding… read more here.
Keywords: p90 ribosomal; kinase domain; kinase; ribosomal kinases ... See more keywords
c‐Jun N‐terminal Kinase mediates prostaglandin‐induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression
Sign Up to like & getrecommendations! Published in 2017 at "Acta Physiologica"
DOI: 10.1111/apha.12758
Abstract: Prostaglandin E2 mediates sympathoexcitation in chronic heart failure (CHF) through EP3 receptors (PTGER3) in the paraventricular nucleus (PVN). The aim of this study was to investigate the role of c‐Jun N‐terminal kinase (JNK) in expressional… read more here.
Keywords: jun terminal; heart failure; terminal kinase; chronic heart ... See more keywords
Inhibition of c-Jun N-terminal kinase ( JNK) suppresses porcine oocyte ageing in vitro
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DOI: 10.17221/7088-cjas
Abstract: Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after rea - ching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphase… read more here.
Keywords: jnk; jun terminal; inhibition; oocyte ageing ... See more keywords
On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
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DOI: 10.3389/fnbeh.2022.1052124
Abstract: c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essential for remembering facts… read more here.
Keywords: jun terminal; object recognition; memory; recognition memory ... See more keywords
Discovery of Novel c-Jun N-Terminal Kinase 1 Inhibitors from Natural Products: Integrating Artificial Intelligence with Structure-Based Virtual Screening and Biological Evaluation
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DOI: 10.3390/molecules27196249
Abstract: c-Jun N-terminal kinase 1 (JNK1) is currently considered a critical therapeutic target for type-2 diabetes. In recent years, there has been a great interest in naturopathic molecules, and the discovery of active ingredients from natural… read more here.
Keywords: natural products; virtual screening; jun terminal; artificial intelligence ... See more keywords
Effect of a Small Selective Inhibitor of C-Jun N-Terminal Kinase on the Inducible mRNA Expression of Interleukin-6 and Interleukin-18
Sign Up to like & getrecommendations! Published in 2019 at "Open Access Macedonian Journal of Medical Sciences"
DOI: 10.3889/oamjms.2019.567
Abstract: BACKGROUND: The expression of many inducible genes, involved in cell growth and differentiation as cytokine genes are regulated by receptor-activated intracellular signalling pathways, including the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase pathway. AIM: We… read more here.
Keywords: jun terminal; interleukin interleukin; interleukin; expression ... See more keywords