An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
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DOI: 10.1038/ncomms14369
Abstract: Cancer immunotherapy by targeting of immune checkpoint molecules has been a research ‘hot-spot' in recent years. Nivolumab, a human monoclonal antibody targeting PD-1, has been widely used clinically since 2014. However, the binding mechanism of… read more here.
Keywords: unexpected terminal; terminal loop; binding nivolumab; dominates binding ... See more keywords
Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop
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DOI: 10.3390/toxins15010006
Abstract: In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in… read more here.
Keywords: loop; peptide bond; terminal loop; activity ... See more keywords