Articles with "terminal modification" as a keyword



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A facile method for monitoring solid-phase peptide synthesis and for N-terminal modification of peptides: synthesis of short peptides for imaging specific cells

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Published in 2019 at "Journal of Chemical Sciences"

DOI: 10.1007/s12039-019-1683-9

Abstract: A simple method for naked-eye detection of free amine groups during solid-phase peptide synthesis is reported. The technique involves base-catalyzed cyclization of 2-(2-oxo-2H-acenaphthylene-1-ylidene)-malononitrile (1) and subsequent oxidative substitution of aryl moiety by free amine group… read more here.

Keywords: terminal modification; solid phase; peptide synthesis; phase peptide ... See more keywords
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AgeMTPT, a Catalyst for Peptide N-Terminal Modification.

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Published in 2022 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00312

Abstract: A key goal of synthetic biology is to enable designed modification of peptides and proteins, both in vivo and in vitro. N- and C-Terminal modification enzymes are crucial in this regard, but there are a… read more here.

Keywords: modification; agemtpt catalyst; terminal modification; substrate ... See more keywords

C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells.

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Published in 2023 at "Chemical communications"

DOI: 10.1039/d2cc05915k

Abstract: Polytheonamide B (1) is an exceptionally large peptide that forms a transmembrane ion channel. The potent cytotoxicity of 1 against MCF-7 cancer cells originates from its two ion transport functions. Compound 1 depolarizes the plasma… read more here.

Keywords: modification polytheonamide; mcf cancer; cancer cells; terminal modification ... See more keywords