Enzymatic Modification of N-Terminal Proline Residues Using Phenol Derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10845
Abstract: A convenient enzymatic strategy is reported for the modification of proline residues in the N-terminal positions of proteins. Using a tyrosinase enzyme isolated from Agaricus bisporus (abTYR), phenols and catechols are oxidized to highly reactive… read more here.
Keywords: proline residues; terminal proline; enzymatic modification; modification ... See more keywords
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47890-5
Abstract: The E3 ligase-degron interaction determines the specificity of the ubiquitin‒proteasome system. We recently discovered that FEM1B, a substrate receptor of Cullin 2-RING ligase (CRL2), recognizes C-degrons containing a C-terminal proline. By solving several cryo-EM structures… read more here.
Keywords: ligase; terminal proline; recognition; crl2fem1b ... See more keywords