A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00681d
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DOI: 10.1039/c8sc00681d
Abstract: A convenient method to bi-terminally modify proteins using recombinant masking groups reveals that H2A.X ubiquitylation opens chromatin during DNA repair. read more here.
Keywords: protein ligation; dna; ligation strategy; terminal protein ... See more keywords
Bromodomain and Extra-Terminal Protein Inhibitors: Biologic Insights and Therapeutic Potential in Pediatric Brain Tumors
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DOI: 10.3390/ph15060665
Abstract: Pediatric brain tumors have surpassed leukemia as the leading cause of cancer-related death in children. Several landmark studies from the last two decades have shown that many pediatric brain tumors are driven by epigenetic dysregulation… read more here.
Keywords: pediatric brain; brain tumors; bromodomain extra; brain ... See more keywords