Effect of evolution of the C‐terminal region on chaperone activity of Hsp70
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4549
Abstract: Dynamic interdomain interactions within the Hsp70 protein is the basis for the allosteric and functional properties of Hsp70s. While Hsp70s are generally conserved in terms of structure, allosteric behavior, and some overlapping functions, Hsp70s also… read more here.
Keywords: hsp70 members; terminal region; region; chaperone activity ... See more keywords
Evaluation of the roles of hydrophobic residues in the N-terminal region of archaeal trehalase in its folding.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11237-7
Abstract: Thermoplasma trehalase Tvn1315 is predicted to be composed of a β-sandwich domain (BD) and a catalytic domain (CD) based on the structure of the bacterial GH15 family glucoamylase (GA). Tvn1315 as well as Tvn1315 (Δ5),… read more here.
Keywords: recovered soluble; terminal region; hydrophobic region; hydrophobic residues ... See more keywords
Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.09.009
Abstract: NKAP is a ubiquitously expressed nucleoplasmic protein that is currently known as a transcriptional regulatory molecule via its interaction with HDAC3 and spliceosomal proteins. Here, we report a disorder of transcriptional regulation due to missense… read more here.
Keywords: transcriptional regulation; disorder transcriptional; marfanoid habitus; terminal region ... See more keywords
Aromatic-rich C-terminal region of LCI is a potent antimicrobial peptide in itself.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.013
Abstract: LCI is a 47-residue antimicrobial peptide produced by Bacillus subtilis. The peptide displays potent activity against plant pathogens, Xanthomonas and Pseudomonas. The peptide takes a compact 3-dimensional structure characterized by a four-stranded β-sheet. The peptide… read more here.
Keywords: terminal region; membrane permeabilization; peptide; antimicrobial peptide ... See more keywords
Specific amino acids from the broad C-terminal region of BMP-2 are crucial for osteogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Bone Reports"
DOI: 10.1016/j.bonr.2021.101092
Abstract: The shortest functional domains of growth factor Bone Morphogenetic Protein 2 (BMP-2) that are dynamical implicated in osteogenesis have been investigated and well characterized. In particular, the broad C-terminal region expanding from Val63 to Arg114… read more here.
Keywords: amino acids; terminal region; broad terminal; osteogenesis ... See more keywords
Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome
Sign Up to like & getrecommendations! Published in 2020 at "Virus Research"
DOI: 10.1016/j.virusres.2020.198222
Abstract: The envelope glycoprotein (E) is the smallest structural component of SARS-CoVs; plays an essential role in the viral replication starting from envelope formation to assembly. The in silico analysis of 2086 whole genome sequences from… read more here.
Keywords: envelope glycoprotein; terminal region; deletion; sars cov ... See more keywords
Glucosyl Platinum(II) Complexes Inhibit Aggregation of the C-Terminal Region of the Aβ Peptide
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.1c03540
Abstract: Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence, many drug discovery processes are oriented to evaluate new compounds that are able to modulate self-recognition mechanisms. Herein, two related glycoconjugate pentacoordinate Pt(II) complexes were… read more here.
Keywords: inhibit aggregation; platinum complexes; terminal region; complexes inhibit ... See more keywords
Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00504
Abstract: The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer’s disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These oligomers are produced prolifically during… read more here.
Keywords: region secondary; nucleation; hydrophobicity; terminal region ... See more keywords
Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20010-2
Abstract: The p53 protein is one of the major cell cycle regulators. The protein is expressed as at least twelve protein isoforms resulting from the use of alternative promoters, alternative splicing or downstream initiation codons. Importantly,… read more here.
Keywords: terminal region; p53 mrna; translation; initiation ... See more keywords
Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1816107
Abstract: ABSTRACT The KCNH family comprises the ERG, EAG, and ELK voltage-activated, potassium-selective channels. Distinct from other K channels, KCNH channels contain unique structural domains, including a PAS (Per-Arnt-Sim) domain in the N-terminal region and a… read more here.
Keywords: erg eag; terminal region; elk channels; gating regulation ... See more keywords
Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad006
Abstract: Accumulating toxic protein assemblies, including Aβ and tau, and dysfunctional mitochondria are associated with synaptic and neuronal loss in Alzheimer's disease (ad). Such accumulations are thought to be due to clearance defects in the autophagy-lysosome… read more here.
Keywords: clearance; health; terminal region; slingshot homolog ... See more keywords