HIV-1 sequences in the epidemic suggest an alternative pathway for the generation of the Long Terminal Repeats
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14135-z
Abstract: To generate the long-terminal repeats (LTR) that border the integrated viral genome, two-strand transfer steps must occur during reverse transcription. Analysis of the genetic polymorphisms that are present in the LTR of HIV-1 heterozygous virions… read more here.
Keywords: terminal repeats; sequences epidemic; strand transfer; long terminal ... See more keywords
Terminal repeats impact collagen triple-helix stability through hydrogen bonding
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03666e
Abstract: Nearly 30% of human proteins have tandem repeating sequences. Structural understanding of the terminal repeats is well-established for many repeat proteins with the common α-helix and β-sheet foldings. By contrast, the sequence–structure interplay of the… read more here.
Keywords: triple helix; terminal repeats; hydrogen bonding; repeat ... See more keywords
Mutations in Long Terminal Repeats κB Transcription Factor Binding Sites in Plasma Virus Among South African People Living with HIV-1.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2018.0293
Abstract: HIV-1 subtype C (HIV-1C) is responsible for the majority of infections in sub-Saharan Africa. We selected 63 plasma-derived samples and generated long terminal repeats (LTRs) amplicons from people living with HIV in South Africa to… read more here.
Keywords: living hiv; binding sites; long terminal; transcription factor ... See more keywords
Degradation and stable maintenance of adeno-associated virus inverted terminal repeats in E. coli
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DOI: 10.1093/nar/gkae1170
Abstract: Abstract Current plasmid propagation in E. coli compromises large inverted repeats, such as inverted terminal repeats (ITRs) of adeno-associated virus (AAV). Direct long-read sequencing analyses upon varying strains and culture conditions revealed ITR instability caused… read more here.
Keywords: adeno associated; degradation stable; inverted terminal; associated virus ... See more keywords
Quadruplex DNA in long terminal repeats in maize LTR retrotransposons inhibits the expression of a reporter gene in yeast
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DOI: 10.1186/s12864-018-4563-7
Abstract: BackgroundMany studies have shown that guanine-rich DNA sequences form quadruplex structures (G4) in vitro but there is scarce evidence of guanine quadruplexes in vivo. The majority of potential quadruplex-forming sequences (PQS) are located in transposable… read more here.
Keywords: reporter gene; terminal repeats; dna; ltr retrotransposons ... See more keywords
Long Terminal Repeats of Gammaretroviruses Retain Stable Expression after Integration Retargeting
Sign Up to like & getrecommendations! Published in 2024 at "Viruses"
DOI: 10.3390/v16101518
Abstract: Retroviruses integrate their genomes into the genomes of infected host cells and form a genetic platform for stable gene expression. Epigenetic silencing can, however, hamper the expression of integrated provirus. As gammaretroviruses (γRVs) preferentially integrate… read more here.
Keywords: integration; gene expression; stable expression; long terminal ... See more keywords