Clues to the Design of Aggregation-Resistant Insulin from Proline Scanning of Highly Amyloidogenic Peptides Derived from the N-Terminal Segment of the A-Chain
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DOI: 10.1021/acs.molpharmaceut.4c00077
Abstract: Insulin aggregation poses a significant problem in pharmacology and medicine as it occurs during prolonged storage of the hormone and in vivo at insulin injection sites. We have recently shown that dominant forces driving the… read more here.
Keywords: insulin; segment chain; design aggregation; terminal segment ... See more keywords
Functional characterization of an N-terminally-truncated mitochondrial porin expressed in Neurospora crassa.
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DOI: 10.1139/cjm-2016-0764
Abstract: Mitochondrial porin, which forms voltage-dependent anion-selective channels (VDAC) in the outer membrane, can be folded into a 19-β-stranded barrel. The N terminus of the protein is external to the barrel and contains α-helical structure. Targeted… read more here.
Keywords: terminal segment; neurospora crassa; functional characterization; porin ... See more keywords
Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
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DOI: 10.3390/molecules27248762
Abstract: The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L… read more here.
Keywords: agt; aggregation; terminal segment; ntt agt ... See more keywords