N-Terminal speciation for native chemical ligation.
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DOI: 10.1039/d0cc01604g
Abstract: Native chemical ligation (NCL) enables the chemical synthesis of peptides via reactions between N-terminal thiolates and C-terminal thioesters under mild, aqueous conditions at pH 7-8. Here we demonstrate quantitatively how thiol speciation at N-terminal cysteines… read more here.
Keywords: native chemical; chemical ligation; terminal speciation;