The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.159
Abstract: In the activation and maintenance of ATR-dependent DNA damage checkpoint, the interaction between the Rad17-RFC2-5 and 9-1-1 complexes is essential, however, the regulatory mechanism of the interaction is not known. Here we show that vertebrate… read more here.
Keywords: terminal tail; rad17; interaction; polyanionic terminal ... See more keywords
Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.076
Abstract: The ATR-dependent DNA damage checkpoint is one of the major checkpoint pathways. The interaction between the Rad17-RFC2-5 and 9-1-1 complexes is central to the ATR-Chk1 pathway. However, little is known about the regulation of the… read more here.
Keywords: terminal tail; promote interaction; rad17; interaction complex ... See more keywords
The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2064073
Abstract: ABSTRACT The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear export of pre-40S particles to the cytoplasm. In addition, the C-terminal tail of Rps15 was suggested to play… read more here.
Keywords: pre; 40s maturation; terminal tail; pre 40s ... See more keywords
Removal of N-terminal tail changes the thermostability of the low-temperature-active exo-inulinase InuAGN25
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineered"
DOI: 10.1080/21655979.2020.1809921
Abstract: ABSTRACT Exo-inulinases are members of the glycoside hydrolase family 32 and function by hydrolyzing inulin into fructose with yields up to 90–95%. The N-terminal tail contributes to enzyme thermotolerance, which plays an important role in… read more here.
Keywords: inulinase inuagn25; terminal tail; exo inulinase; tail ... See more keywords
Dynamics of the nucleosomal histone H3 N-terminal tail revealed by high precision single-molecule FRET
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1186
Abstract: Abstract Chromatin compaction and gene accessibility are orchestrated by assembly and disassembly of nucleosomes. Although the disassembly process was widely studied, little is known about the structure and dynamics of the disordered histone tails, which… read more here.
Keywords: terminal tail; single molecule; dna; histone terminal ... See more keywords
SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0278448
Abstract: SHP-1 is a cytosolic tyrosine phosphatase that is primarily expressed in hematopoietic cells. It acts as a negative regulator of numerous signaling pathways and controls multiple cellular functions involved in cancer pathogenesis. This study describes… read more here.
Keywords: shp; terminal tail; tyrosine phosphatase; binding src ... See more keywords
The N-terminal tail coordinates with carbohydrate recognition domain to mediate galectin-3 induced apoptosis in T cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17760
Abstract: Galectin-3 is a galectin with a unique flexible N-terminal tail (NT) connected to the conserved carbohydrate recognition domain (CRD). Galectin-3 is associated with tumor immune tolerance and exhibits an ability to induce T cell apoptosis.… read more here.
Keywords: terminal tail; galectin; apoptosis; induced apoptosis ... See more keywords
Influence of the Dynamically Disordered N-Terminal Tail Domain on the Amyloid Core Structure of Human Y145Stop Prion Protein Fibrils
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.841790
Abstract: The Y145Stop mutant of human prion protein (huPrP23-144) is associated with a familial prionopathy and provides a convenient in vitro model for investigating amyloid strains and cross-seeding barriers. huPrP23-144 fibrils feature a compact and relatively… read more here.
Keywords: core; structure; terminal tail; amyloid core ... See more keywords
Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22126308
Abstract: APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions, acting as a redox regulator of transcription… read more here.
Keywords: terminal tail; dna repair; mechanisms regulating; dna ... See more keywords