The suppression of premature termination codons and the repair of splicing mutations in CFTR
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.09.017
Abstract: HighlightsPremature termination codons are susceptible to constitutive readthrough.Readthrough compounds may restore synthesis of a functional full‐length protein.Mutations that alter splicing induce inappropriate inclusion or skipping of an exon.Oligonucleotide‐based therapies inhibit or activate specific splicing events.… read more here.
Keywords: codons repair; termination codons; suppression premature; splicing mutations ... See more keywords
Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer
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DOI: 10.3390/biomedicines9060618
Abstract: Upstream open reading frame (uORF)-mediated translational control has emerged as an important regulatory mechanism in human health and disease. However, a systematic search for cancer-associated somatic uORF mutations has not been performed. Here, we analyzed… read more here.
Keywords: termination codons; reading frame; upstream open; cancer ... See more keywords
Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants
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DOI: 10.7554/elife.57834
Abstract: Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay… read more here.
Keywords: atpase; termination codons; upf1 atpase; atpase mutants ... See more keywords