β‐sheets mediate the conformational change and allosteric signal transmission between the AsLOV2 termini
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27344
Abstract: Avena sativa phototropin 1 light‐oxygen‐voltage 2 domain (AsLOV2) is a model protein of Per‐Arnt‐Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change begins with the unfolding of the… read more here.
Keywords: conformational change; termini; signal transmission; allosteric signal ... See more keywords
A novel triplex isobaric termini labeling quantitative approach for simultaneously supplying three quantitative sources.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.11.004
Abstract: Benefiting from high sensitivity and great ability to measure multiple samples simultaneously, isobaric tandem Mass spectrometry (MS2) quantification has been widely applied for protein biomarker screening. Here, a newly developed isobaric MS2 quantification method named… read more here.
Keywords: isobaric termini; triplex qitl; termini; termini labeling ... See more keywords
Cytosolic N- and C-Termini of the Aspergillus nidulans FurE Transporter Contain Distinct Elements that Regulate by Long Range Effects Function and Specificity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.07.013
Abstract: FurE, a member of the NCS1 family, is an Aspergillus nidulans transporter specific for uracil, allantoin and uric acid. Recently, we showed that C- or N-terminally truncated FurE versions are blocked for endocytosis and, surprisingly,… read more here.
Keywords: range effects; termini; long range; cytosolic termini ... See more keywords
In-Depth Analysis of C Terminomes Based on LysC Digestion and Site-Selective Dimethylation.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b05338
Abstract: Analysis of protein C termini is very important for functional annotations of proteomes, while proteome-wide C termini analysis still poses substantial challenges. Here we described a simple and robust strategy for specific isolation of protein… read more here.
Keywords: lysc digestion; analysis; protein termini; termini ... See more keywords
A Versatile Enzymatic Pathway for Modification of Peptide C‑Termini
Sign Up to like & getrecommendations! Published in 2025 at "ACS Central Science"
DOI: 10.1021/acscentsci.5c01243
Abstract: Advances in bioinformatics have enabled the discovery of unique enzymatic reactions, particularly for ribosomally synthesized and post-translationally modified peptides (RiPPs). The recently discovered daptides, peptides with their C-terminus replaced by an amine, represent one such… read more here.
Keywords: peptide termini; versatile enzymatic; termini; enzymatic pathway ... See more keywords
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0322-6
Abstract: Protein–protein interactions between E3 ubiquitin ligases and protein termini help shape the proteome. These interactions are sensitive to proteolysis, which alters the ensemble of cellular N and C termini. Here we describe a mechanism wherein… read more here.
Keywords: caspase; latent termini; ubiquitin ligase; termini ... See more keywords
PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07910-5
Abstract: The worrying rise of antibiotic resistance in pathogenic bacteria is leading to a renewed interest in bacteriophages as a treatment option. Novel sequencing technologies enable description of an increasing number of phage genomes, a critical… read more here.
Keywords: sequencing data; tool fast; phage; phageterm tool ... See more keywords
Systematic Assessment of Protein C-Termini Mutated in Human Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020355
Abstract: All proteins have a carboxyl terminus, and we previously summarized eight mutations in binding and trafficking sequence determinants in the C-terminus that, when disrupted, cause human diseases. These sequence elements for binding and trafficking sites,… read more here.
Keywords: systematic assessment; disease; binding trafficking; cause disease ... See more keywords
PRG3 and PRG5 C-Termini: Important Players in Early Neuronal Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113007
Abstract: The functional importance of neuronal differentiation of the transmembrane proteins’ plasticity-related genes 3 (PRG3) and 5 (PRG5) has been shown. Although their sequence is closely related, they promote different morphological changes in neurons. PRG3 was… read more here.
Keywords: prg5 termini; termini; early neuronal; neuronal differentiation ... See more keywords
eIF3 engages with 3’-UTR termini of highly translated mRNAs
Sign Up to like & getrecommendations! Published in 2025 at "eLife"
DOI: 10.7554/elife.102977
Abstract: Stem cell differentiation involves a global increase in protein synthesis to meet the demands of specialized cell types. However, the molecular mechanisms underlying this translational burst and the involvement of initiation factors remains largely unknown.… read more here.
Keywords: utr termini; termini; highly translated; eif3 engages ... See more keywords