Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles
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DOI: 10.1371/journal.pgen.1010560
Abstract: The cilium acts as an antenna receiving and sending signals, the latter via extracellular vesicles (EVs). In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 (PC1) and polycystin-2 (PC2)… read more here.
Keywords: extracellular vesicles; ciliary evs; lov; tracking termini ... See more keywords