Roles of the genomic sequence surrounding the stem‐loop structure in the junction region including the 3′ terminus of open reading frame 1 in hepatitis E virus replication
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25215
Abstract: Hepatitis E virus (HEV), a member of the family Hepeviridae, causes both acute and chronic viral hepatitis. We have previously demonstrated that the stem‐loop structure in the junction region (JR) of HEV genome plays a… read more here.
Keywords: terminus; hev replication; hepatitis; replication ... See more keywords
APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0468-5
Abstract: Deciphering the role of any protein in a cell requires knowledge of the structure, subcellular localization, and the topological orientation of the protein within the relevant cells. The Sigma-1 receptor (S1R) largely localized to the… read more here.
Keywords: protein; terminus; topology; s1r ... See more keywords
The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.123
Abstract: Ubl4A is a small ubiquitin-like protein involved in diverse cellular functions. We have shown that Ubl4A is critical for survival of the starvation-mediated cell death in vivo. The underlying mechanism for this is through interaction with… read more here.
Keywords: arp2 complex; death; arp2; terminus ... See more keywords
The N-terminus of MTRR plays a role in MTR reactivation cycle beyond electron transfer.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103836
Abstract: In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. The N-terminus of MTRR containing a conserved domain of… read more here.
Keywords: mtrr; electron transfer; terminus; terminus mtrr ... See more keywords
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.051
Abstract: SUMMARY TREX1 mutations are associated with several auto-immune and inflammatory diseases. The N-terminal DNase domain of TREX1 is important for preventing self-DNA from activating the interferon response. The C terminus of TREX1 is required for… read more here.
Keywords: mitotic phosphorylation; trex1; terminus; phosphorylation trex1 ... See more keywords
Identification of a second Klotho interaction site in the C terminus of FGF23.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108665
Abstract: FGF23 interacts with a FGFR/KL-receptor complex to propagate cellular signaling, where its C-terminal C26 peptide is critical for engaging the co-receptor KL. We identify a distinct peptide sequence C28 residing in the FGF23 C terminus… read more here.
Keywords: terminus; terminus fgf23; identification second; site ... See more keywords
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00072
Abstract: Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin (Noct) is a rhythmically expressed gene regulated… read more here.
Keywords: nocturnin; terminus; amino terminus; activity ... See more keywords
Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00363
Abstract: We set out to determine whether the C-terminus (amino acids 481–798) of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a regulatory metabolic protein involved in mitochondrial biogenesis, and respiration, is an arginine methyltransferase… read more here.
Keywords: methylation; temperature; terminus; arginine methylation ... See more keywords
Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00803
Abstract: Aldehyde dehydrogenase 7A1 (ALDH7A1) catalyzes the terminal step of lysine catabolism, the NAD+-dependent oxidation of α-aminoadipate semialdehyde to α-aminoadipate. Structures of ALDH7A1 reveal the C-terminus is a gate that opens and closes in response to… read more here.
Keywords: state; terminus; dehydrogenase 7a1; catalytic activity ... See more keywords
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16564-3
Abstract: As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone and non-aggregation prone intermediates, but identifying these within the dynamic ensemble of monomeric conformations is difficult.… read more here.
Keywords: aggregation; aggregation prone; terminus; asyn ... See more keywords
Variable G protein determinants of GPCR coupling selectivity
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905993116
Abstract: Significance G protein-coupled receptors (GPCRs) regulate a wide variety of important cellular processes and are targeted by a large fraction of approved drugs. GPCRs signal by activating heterotrimeric G proteins and must couple to a… read more here.
Keywords: protein; terminus; coupling selectivity; coupled receptors ... See more keywords