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   Articles with "ternary complex" as a keyword



Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug

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recommendations! Published in 2021 at "Advanced Optical Materials"

DOI: 10.1002/adom.202100966

Abstract: Highly effective transporting and real‐time monitoring of the drug delivery system (DDS) has attracted much attention from researchers. However, separately tracking the multiple components in a complex DDS as well as its delivery process is… read more here.

Keywords: modular peptides; drug; delivery; ternary complex ... See more keywords

Fabrication and characterization of gelatin-EGCG-pectin ternary complex: Formation mechanism, emulsion stability, and structure.

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recommendations! Published in 2022 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.12240

Abstract: BACKGROUND Protein-polyphenol-polysaccharide ternary complex particles have better emulsion interfacial stability compared to protein-polysaccharide binary complexes. However, knowledge is scarce when it comes to the fabrication of protein-polyphenol-polysaccharide ternary complexes as interfacial stabilizers and the interactions… read more here.

Keywords: stability; egcg; pectin; ternary complex ... See more keywords

Binding orientation and interaction of bile salt in its ternary complex with pancreatic lipase-colipase system.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.04.018

Abstract: The interfacial activity of pancreatic lipases (PL) depends on the presence of colipase and bile salt. The activity of PL is inhibited by micellar concentrations of bile salt which can be restored by the addition… read more here.

Keywords: bile salt; ternary complex; colipase; lipase colipase ... See more keywords

New lanthanide ternary complex system in electrospun nanofibers: Assembly, physico-chemical property and sensor application

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recommendations! Published in 2019 at "Chemical Engineering Journal"

DOI: 10.1016/j.cej.2018.10.003

Abstract: Abstract The generation of novel optical sensing structures through the lanthanide coordination has been a key scientific endeavor. The design of molecular indicator for chemical response is derived from the assembly of a polymeric-based ternary… read more here.

Keywords: ternary complex; system; new lanthanide; complex system ... See more keywords
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Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.

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recommendations! Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113686

Abstract: Pathway activating mutations of the transcription factor NRF2 and its negative regulator KEAP1 are strongly correlative with poor clinical outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the strong genetic support and therapeutic potential… read more here.

Keywords: ternary complex; dna; chemistry; cancer ... See more keywords

Curcumin, casein and soy polysaccharide ternary complex nanoparticles for enhanced dispersibility, stability and oral bioavailability of curcumin

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recommendations! Published in 2020 at "Food bioscience"

DOI: 10.1016/j.fbio.2020.100569

Abstract: Abstract Curcumin, casein and soy soluble polysaccharide ternary complex nanoparticles were produced in the water phase using alkaline dissolution, acidification and high-pressure homogenization. FTIR spectra showed that hydrogen bonding, hydrophobic and electrostatic interactions led to… read more here.

Keywords: ternary complex; curcumin casein; complex nanoparticles; casein soy ... See more keywords

Copper2+ Binding to α-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate.

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recommendations! Published in 2019 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.9b02644

Abstract: α-Synuclein (αSyn) forms amyloid fibrils in the neurons of Parkinson's disease (PD) patients'. Despite a role for Cu2+ in accelerating αSyn fibril formation, coupled with reports of copper dis-homeostasis in PD, there remain controversies surrounding… read more here.

Keywords: ternary complex; macrochelate; form ternary; cu2 ... See more keywords

PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes

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recommendations! Published in 2020 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.0c00589

Abstract: Proteolysis-targeting chimeras (PROTACs), which induce degradation by recruitment of an E3 ligase to a target protein, are gaining much interest as a new pharmacological modality. However, designing PROTACs is challenging. Formation of a ternary complex… read more here.

Keywords: protein; ternary complex; ternary complexes; protac ... See more keywords

Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies.

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recommendations! Published in 2020 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.0c00897

Abstract: Extending upon our previous publication (Drummond, M., Williams, C., In Silico Modeling of PROTAC-mediated Ternary Complexes: Validation and Application, J. Chem. Inf. Model., 2019, 59, 1634-1644), in this work two additional computational methods are presented… read more here.

Keywords: ternary complex; protac mediated; protac; mediated ternary ... See more keywords

Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search

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recommendations! Published in 2025 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.5c00102

Abstract: Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that recruit E3 ubiquitin ligases to a target protein and induce its ubiquitination by forming a ternary complex. However, the structural dynamics underlying the complex formation and degradation… read more here.

Keywords: distribution; extensive conformational; conformational search; ternary complex ... See more keywords

Interplay of PROTAC Complex Dynamics for Undruggable Targets: Insights into Ternary Complex Behavior and Linker Design.

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recommendations! Published in 2024 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.4c00189

Abstract: Protein degraders, such as bifunctional proteolysis-targeting chimeras (PROTACs), selectively eliminate target proteins by leveraging the natural protein degradation machinery. PROTACs bridge the target protein with an E3 ligase, which induces ubiquitination and degradation. Investigating ternary… read more here.

Keywords: complex dynamics; protac complex; linker; ternary complex ... See more keywords