Modular‐Peptides‐Based Ternary Complex for Precisely Tracking the Targeted Process and Delivery of Gene/Chemo‐Drug
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Optical Materials"
DOI: 10.1002/adom.202100966
Abstract: Highly effective transporting and real‐time monitoring of the drug delivery system (DDS) has attracted much attention from researchers. However, separately tracking the multiple components in a complex DDS as well as its delivery process is… read more here.
Keywords: modular peptides; drug; delivery; ternary complex ... See more keywords
Fabrication and characterization of gelatin-EGCG-pectin ternary complex: Formation mechanism, emulsion stability, and structure.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12240
Abstract: BACKGROUND Protein-polyphenol-polysaccharide ternary complex particles have better emulsion interfacial stability compared to protein-polysaccharide binary complexes. However, knowledge is scarce when it comes to the fabrication of protein-polyphenol-polysaccharide ternary complexes as interfacial stabilizers and the interactions… read more here.
Keywords: stability; egcg; pectin; ternary complex ... See more keywords
Binding orientation and interaction of bile salt in its ternary complex with pancreatic lipase-colipase system.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.018
Abstract: The interfacial activity of pancreatic lipases (PL) depends on the presence of colipase and bile salt. The activity of PL is inhibited by micellar concentrations of bile salt which can be restored by the addition… read more here.
Keywords: bile salt; ternary complex; colipase; lipase colipase ... See more keywords
New lanthanide ternary complex system in electrospun nanofibers: Assembly, physico-chemical property and sensor application
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2018.10.003
Abstract: Abstract The generation of novel optical sensing structures through the lanthanide coordination has been a key scientific endeavor. The design of molecular indicator for chemical response is derived from the assembly of a polymeric-based ternary… read more here.
Keywords: ternary complex; system; new lanthanide; complex system ... See more keywords
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113686
Abstract: Pathway activating mutations of the transcription factor NRF2 and its negative regulator KEAP1 are strongly correlative with poor clinical outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the strong genetic support and therapeutic potential… read more here.
Keywords: ternary complex; dna; chemistry; cancer ... See more keywords
Curcumin, casein and soy polysaccharide ternary complex nanoparticles for enhanced dispersibility, stability and oral bioavailability of curcumin
Sign Up to like & getrecommendations! Published in 2020 at "Food bioscience"
DOI: 10.1016/j.fbio.2020.100569
Abstract: Abstract Curcumin, casein and soy soluble polysaccharide ternary complex nanoparticles were produced in the water phase using alkaline dissolution, acidification and high-pressure homogenization. FTIR spectra showed that hydrogen bonding, hydrophobic and electrostatic interactions led to… read more here.
Keywords: ternary complex; curcumin casein; complex nanoparticles; casein soy ... See more keywords
Copper2+ Binding to α-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b02644
Abstract: α-Synuclein (αSyn) forms amyloid fibrils in the neurons of Parkinson's disease (PD) patients'. Despite a role for Cu2+ in accelerating αSyn fibril formation, coupled with reports of copper dis-homeostasis in PD, there remain controversies surrounding… read more here.
Keywords: ternary complex; macrochelate; form ternary; cu2 ... See more keywords
PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.0c00589
Abstract: Proteolysis-targeting chimeras (PROTACs), which induce degradation by recruitment of an E3 ligase to a target protein, are gaining much interest as a new pharmacological modality. However, designing PROTACs is challenging. Formation of a ternary complex… read more here.
Keywords: protein; ternary complex; ternary complexes; protac ... See more keywords
Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00897
Abstract: Extending upon our previous publication (Drummond, M., Williams, C., In Silico Modeling of PROTAC-mediated Ternary Complexes: Validation and Application, J. Chem. Inf. Model., 2019, 59, 1634-1644), in this work two additional computational methods are presented… read more here.
Keywords: ternary complex; protac mediated; protac; mediated ternary ... See more keywords
A binding site hotspot map of the FKBP12-rapamycin-FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b03764
Abstract: Structural characterization of small molecule bind-ing site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site maps provide… read more here.
Keywords: ternary complex; binding site; photo; site ... See more keywords
Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59966-5
Abstract: Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD… read more here.
Keywords: ternary complex; complex formation; formation; tpd molecules ... See more keywords