Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800120
Abstract: Prenyltransferase (PT) and terpene synthase (TPS) are key enzymes in the formation of the basic carbon skeletons of terpenoids. The PTs determine the prenyl carbon chain length, whereas TPSs generate the structural complexity of the… read more here.
Keywords: synthases possessing; terpene; terpene synthases; terpene cyclization ... See more keywords
Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100484
Abstract: Terpenoids are a highly diverse group of natural products with considerable industrial interest. Increasingly, engineered microbes are used for the production of terpenoids to replace natural extracts and chemical synthesis. Terpene synthases (TSs) show a… read more here.
Keywords: terpene synthases; class terpene; predictive engineering; engineering class ... See more keywords
On the Evolution and Functional Diversity of Terpene Synthases in the Pinus Species: A Review
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-020-09930-8
Abstract: In the biosynthesis of terpenoids, the ample catalytic versatility of terpene synthases (TPS) allows the formation of thousands of different molecules. A steadily increasing number of sequenced plant genomes invariably show that the TPS gene… read more here.
Keywords: functional diversity; evolution functional; terpene synthases; diversity terpene ... See more keywords
Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products.
Sign Up to like & getrecommendations! Published in 2023 at "ACS catalysis"
DOI: 10.1021/acscatal.2c05598
Abstract: Terpene synthases (TPSs), known gatekeepers of terpenoid diversity, are the main targets for enzyme engineering attempts. To this end, we have determined the crystal structure of Agrocybe pediades linalool synthase (Ap.LS), which has been recently… read more here.
Keywords: terpene; synthase; terpene synthases; linear cyclic ... See more keywords
Crystal structure and functional analysis of large-terpene synthases belonging to a newly found subclass† †Electronic supplementary information (ESI) available: One PDF document and three movie files. See DOI: 10.1039/c8sc00289d
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c8sc00289d
Abstract: The first crystal structure of a large-terpene synthase elucidated two novel Asp rich motifs and a new subclass of terpene synthases. read more here.
Keywords: large terpene; crystal structure; subclass; terpene synthases ... See more keywords
Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03644d
Abstract: Fungal bifunctional terpene synthases (BFTSs) reportedly associate with a series of new skeletons of di/sesterterpenes. However, the molecular mechanisms underlying the variabilities in the ring system of BFTS-catalyzed products are not well understood. In this… read more here.
Keywords: bifunctional terpene; conversion bicyclic; terpene; bicyclic polycyclic ... See more keywords
Genome mining of cryptic bisabolenes that were biosynthesized by intramembrane terpene synthases from Antrodia cinnamomea
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0033
Abstract: Terpenoids represent the largest structural family of natural products (NPs) and have various applications in the pharmaceutical, food and fragrance industries. Their diverse scaffolds are generated via a multi-step cyclization cascade of linear isoprene substrates… read more here.
Keywords: antrodia cinnamomea; mining cryptic; genome mining; bisabolene ... See more keywords
Terpene Biosynthesis in Red Algae Is Catalyzed by Microbial Type But Not Typical Plant Terpene Synthases1[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.01413
Abstract: Comprehensive genomic analysis and experimental verification provide conclusive evidence that red algal terpenes are biosynthesized by microbial-type terpene synthases. Red algae (Rhodophyta) and land plants belong to the monophyletic clade Archaeplastida, and taxa of both… read more here.
Keywords: typical plant; terpene synthases; red algae; terpene ... See more keywords
Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Cell Factories"
DOI: 10.1186/s12934-022-01791-8
Abstract: Background Terpene synthases are versatile catalysts in all domains of life, catalyzing the formation of an enormous variety of different terpenoid secondary metabolites. Due to their diverse bioactive properties, terpenoids are of great interest as… read more here.
Keywords: product; sesquiterpene; terpene synthases; production ... See more keywords
Bacterial terpene synthases neighbour-joining tree.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS ONE"
DOI: 10.1371/journal.pone.0232220.s005
Abstract: Neighbour-joining tree constructed from the amino acid sequences of characterized terpene synthases in this study (underlined) and in previous studies. Geosmin synthases (dark red), 2-methylisoborneol synthases (orange), monoterpene (light blue), diterpene (dark blue) and sesquiterpene… read more here.
Keywords: bacterial terpene; terpene; terpene synthases; neighbour joining ... See more keywords
Evidence that nuclear receptors are related to terpene synthases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-21-0156
Abstract: Ligand-activated nuclear receptors (NRs) orchestrate development, growth, and reproduction across all animal lifeforms – the Metazoa – but how NRs evolved remains mysterious. Given the NR ligands including steroids and retinoids are predominantly terpenoids, we… read more here.
Keywords: nuclear receptors; evidence nuclear; terpene synthases; related terpene ... See more keywords